Sports-Statin Interaction: Ensuring Safe and Smart Synergy

Abstract

Both sports (physical activity) and statins are recommended for the prevention and management of atherosclerotic cardiovasculardisease. The synergy that they create in risk reduction, however, may turn dysfunctional at times. Statin usage is associated witha risk of muscle-related conditions including myalgia, myositis and rhabdomyolysis. This risk is exacerbated by unaccustomedphysical activity, exercise or sports. The communication shares practical and pragmatic suggestions regarding the preventionand management of the potential sports-statin interactions that may occur. It also highlights the need to consider drug-lifestyleinteractions, apart from conventional drug-drug interactions.