Infrared-Driven Rapid Quantification of Magnetophoretically Trapped Drug

IF 2.5 3区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Journal of Microelectromechanical Systems Pub Date : 2024-02-23 DOI:10.1109/JMEMS.2024.3365538

Vinit Kumar Yadav;Pankaj Pathak;Preetha Ganguly;Prashant Mishra;Samaresh Das;Dhiman Mallick

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引用次数: 0

Abstract

This work presents a rapid quantification approach for on-chip, trapped magnetic nanoparticle drug conjugate (MD) and tests its in-vitro efficacy using an integrated piezoelectric/ferromagnetic bilayer structure-based magnetoelectric sensor coupled magnetic microfluidic device. The MD trapping is accomplished using triangular-shaped, patterned permanent magnet integrated using elastomer-free, pure NdFeB micro-powder that generates magnetic forces up to 0.2 pN on MDs. This trapped drug is flushed in a local concentration at the outlet well of the microfluidic device, where the magnetoelectric sensor is placed. The concentration and position of the trapped MD varies with the change in flow rate from 0.01-

$0.1 ~\mu \text{l}$

/min. Upon exposure to IR (Infrared) irradiation pulses, the sensor detects 0.33-0.21 nA current for 0-

$500 ~\mu \text{g}$

/ml concentration due to the pyroelectric effect and exhibits remarkable sensitivity (0.33 nA.ml/

$\mu \text{g}$

) and response time (

$ < 2\text{s}$

). [2023-0218]

查看原文本刊更多论文

JMEMS Letters.1pt 红外驱动的磁浮药物快速定量技术

本研究提出了一种片上磁性纳米粒子药物共轭物（MD）快速定量方法，并利用基于压电/铁磁双层结构的磁电传感器耦合磁性微流控装置测试了其体外药效。MD 捕获是通过使用无弹性纯钕铁硼微粉集成的三角形图案永磁体来实现的，该永磁体可对 MD 产生高达 0.2 pN 的磁力。磁电传感器放置在微流控装置的出口孔中，这些被捕获的药物在出口孔中形成局部浓度。被捕获的 MD 的浓度和位置随 0.01- 0.1 ~mu \text{l}$ /min 的流速变化而变化。暴露于 IR（红外线）辐照脉冲时，由于热释电效应，传感器可检测到 0- 500 美元（mu \ text{g}$ /ml ）浓度下的 0.33-0.21 nA 电流，并表现出显著的灵敏度（0.33 nA.ml/ $ mu \ text{g}$ ）和响应时间（$ < 2\text{s}$ ）。[2023-0218]

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来源期刊

Journal of Microelectromechanical Systems 工程技术-工程：电子与电气

CiteScore

6.20

自引率

7.40%

发文量

115

审稿时长

7.5 months

期刊介绍： The topics of interest include, but are not limited to: devices ranging in size from microns to millimeters, IC-compatible fabrication techniques, other fabrication techniques, measurement of micro phenomena, theoretical results, new materials and designs, micro actuators, micro robots, micro batteries, bearings, wear, reliability, electrical interconnections, micro telemanipulation, and standards appropriate to MEMS. Application examples and application oriented devices in fluidics, optics, bio-medical engineering, etc., are also of central interest.