Neurofilaments: Novel findings and future challenges

IF 6 2区 生物学 Q1 CELL BIOLOGY
Jessy V. van Asperen, Farah Kotaich, Damien Caillol, Pascale Bomont
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引用次数: 0

Abstract

Neurofilaments (NFs) are abundant cytoskeletal proteins that emerge as a critical hub for cell signalling within neurons. As we start to uncover essential roles of NFs in regulating microtubule and organelle dynamics, nerve conduction and neurotransmission, novel discoveries are expected to arise in genetics, with NFs identified as causal genes for various neurodegenerative diseases. This review will discuss how the latest advances in fundamental and translational research illuminate our understanding of NF biology, particularly their assembly, organisation, transport and degradation. We will emphasise the notion that filaments are not one entity and that future challenges will be to apprehend their diverse composition and structural heterogeneity and to scrutinize how this regulates signalling, sustains neuronal physiology and drives pathophysiology in disease.

神经丝:新发现与未来挑战
神经丝(NFs)是一种丰富的细胞骨架蛋白,是神经元内细胞信号传导的关键枢纽。随着我们开始发现 NFs 在调节微管和细胞器动力学、神经传导和神经传递方面的重要作用,预计遗传学领域也将出现新发现,NFs 将被确定为各种神经退行性疾病的致病基因。本综述将讨论基础研究和转化研究的最新进展如何阐明我们对 NF 生物学,尤其是其组装、组织、运输和降解的理解。我们将强调丝状物并非一个整体的概念,未来的挑战将是理解它们的不同组成和结构异质性,并仔细研究它们是如何调节信号、维持神经元生理机能和驱动疾病的病理生理学的。
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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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