Dynamic Role of miRNAs in Salivary Gland Carcinomas: From Biomarkers to Therapeutic Targets.

IF 3.2 Q2 PATHOLOGY

Head & Neck Pathology Pub Date : 2024-02-23 DOI:10.1007/s12105-023-01603-4

Talita de Carvalho Kimura, Reydson Alcides de Lima-Souza, Tayná Figueiredo Maciel, Luiz Paulo Kowalski, Cláudia Malheiros Coutinho-Camillo, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano

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Abstract

Background: Salivary gland carcinomas (SGCs) are a rare group of malignant neoplasms of the head and neck region. MicroRNAs (miRNAs) are a class of small non-coding RNAs that have been associated with the control biological process and oncogenic mechanism by the regulation of gene expression at the post-transcriptional level. Recent evidence has suggested that miRNA expression may play a role in the tumorigenesis and carcinogenesis process in SGCs.

Methods: This review provides a comprehensive literature review of the role of miRNAs expression in SGCs focusing on the diagnostic, prognostic, and therapeutic applications.

Results: In this review, numerous dysregulated miRNAs have demonstrated an oncogenic and suppressor role in SGCs.

Conclusion: In the future, these miRNAs may eventually constitute useful diagnostic and prognostic biomarkers that may lead to a better understanding of SGCs oncogenesis. Additionally, the development of therapeutic agents based on miRNAs may be a promising target in SGC treatment.

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miRNA 在唾液腺癌中的动态作用：从生物标志物到治疗靶点

背景：唾液腺癌（Salivary gland carcinomas，SGCs）是头颈部罕见的恶性肿瘤。微小 RNA（miRNA）是一类小型非编码 RNA，通过在转录后水平调控基因表达，与控制生物过程和致癌机制有关。最近的证据表明，miRNA 的表达可能在 SGCs 的肿瘤发生和癌变过程中发挥作用：本综述对 miRNAs 在 SGCs 中的表达作用进行了全面的文献综述，重点关注其在诊断、预后和治疗方面的应用：结果：在这篇综述中，许多失调的 miRNA 在 SGCs 中显示出致癌和抑制作用：结论：未来，这些 miRNAs 最终可能成为有用的诊断和预后生物标志物，从而使人们更好地了解 SGCs 的致癌过程。此外，开发基于 miRNAs 的治疗药物可能是治疗 SGCs 的一个有前途的目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.

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