Evaluation of the GeneXpert MTB/RIF to diagnose tuberculosis in a public health laboratory.

IF 2.1 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Revista de saude publica Pub Date : 2024-02-19 eCollection Date: 2024-01-01 DOI:10.11606/s1518-8787.2024058005306

Mohanna Damasceno Arbués, Maria Lúcia Rosa Rossetti

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引用次数: 0

Abstract

Objectives: To evaluate the performance of geneXpert MTB/Rif versus conventional methods (bacilloscopy and culture) in the diagnosis of tuberculosis in a Central Public Health Laboratory (LACEN, Tocantins), Northern Brazil.

Methods: Retrospective study, with information from 1,973 suspected cases of tuberculosis from patients treated from January 2015 to December 2020.

Results: From the culture (reference standard), the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the geneXpert MTB/Rif were 100%, 97%, 74%, 100%, and 97%, respectively, against 85%, 98%, 80%, 98%, and 97% of bacilloscopy.

Conclusions: The geneXpert MTB/Rif performed similarly to culture and better than bacilloscopy. Although positive cases with negative culture should be evaluated with caution, its routine use is important for the early detection of tuberculosis.

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对公共卫生实验室使用 GeneXpert MTB/RIF 诊断结核病的评估。

目的评估基因Xpert MTB/Rif与传统方法（杆菌镜检查和培养）在巴西北部中央公共卫生实验室（LACEN，托坎廷斯）诊断结核病中的性能：方法：回顾性研究，收集2015年1月至2020年12月期间接受治疗的1973例肺结核疑似病例的信息：从培养（参考标准）来看，基因 Xpert MTB/Rif 的敏感性、特异性、阳性预测值、阴性预测值和准确性分别为 100%、97%、74%、100% 和 97%，而杆菌镜检查的敏感性、特异性、阳性预测值、阴性预测值和准确性分别为 85%、98%、80%、98% 和 97%：结论：基因 Xpert MTB/Rif 的效果与培养相似，但优于杆菌镜检查。虽然对培养阴性的阳性病例应谨慎评估，但它的常规使用对结核病的早期发现非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista de saude publica PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

3.60%

发文量

审稿时长

4-8 weeks

期刊介绍： The Revista de Saúde Pública has the purpose of publishing original scientific contributions on topics of relevance to public health in general.