Iron Deposition in Parkinson's Disease: A Mini-Review.

IF 3.6 4区 医学 Q3 CELL BIOLOGY
Weiqi Zeng, Jin Cai, Lei Zhang, Qiwei Peng
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引用次数: 0

Abstract

Iron deposition is crucial pathological changes observed in patients with Parkinson's disease (PD). Recently, scientists have actively explored therapeutic approaches targeting iron deposition in PD. However, several clinical studies have failed to yield consistent results. In this review, we provide an overview of iron deposition in PD, from both basic research and clinical perspectives. PD patients exhibit abnormalities in various iron metabolism-related proteins, leading to disruptions in iron distribution, transport, storage, and circulation, ultimately resulting in iron deposition. Excess iron can induce oxidative stress and iron-related cell death, and exacerbate mitochondrial dysfunction, contributing to the progression of PD pathology. Magnetic resonance imaging studies have indicated that the characteristics of iron deposition in the brains of PD patients vary. Iron deposition correlates with the clinical symptoms of PD, and patients with different disease courses and clinical presentations display distinct patterns of iron deposition. These iron deposition patterns may contribute to PD diagnosis. Iron deposition is a promising target for PD treatment. However, further research is required to elucidate the underlying mechanisms and their impacts on PD.

帕金森病中的铁沉积:微型综述。
铁沉积是帕金森病(PD)患者的重要病理变化。最近,科学家们积极探索针对帕金森病铁沉积的治疗方法。然而,一些临床研究未能取得一致的结果。在这篇综述中,我们从基础研究和临床角度概述了帕金森病的铁沉积。帕金森病患者的各种铁代谢相关蛋白出现异常,导致铁的分布、运输、储存和循环发生紊乱,最终造成铁沉积。过量的铁可诱发氧化应激和与铁相关的细胞死亡,并加剧线粒体功能障碍,从而导致帕金森病的病理发展。磁共振成像研究表明,帕金森病患者大脑中铁沉积的特征各不相同。铁沉积与帕金森病的临床症状相关,不同病程和临床表现的患者表现出不同的铁沉积模式。这些铁沉积模式可能有助于帕金森病的诊断。铁沉积是有希望治疗帕金森病的靶点。然而,要阐明其潜在机制及其对帕金森病的影响,还需要进一步的研究。
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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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