Duration-specific association between plasma IGFBP7 levels and diabetic complications in patients with type 2 diabetes mellitus

IF 1.6 4区医学 Q4 CELL BIOLOGY

Growth Hormone & Igf Research Pub Date : 2024-02-21 DOI:10.1016/j.ghir.2024.101574

Xiaoyan Zhu , Fei Liang , Jieyun Yin , Xiaoliang Li , Lai Jiang , Yan Gao , Yan Lu , Yihe Hu , Ningbin Dai , Jian Su , Zhuoqiao Yang , Mengxin Yao , Yue Xiao , Wenxin Ge , Yue Zhang , Yi Zhong , Jun Zhang , Ming Wu

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引用次数: 0

Abstract

Objective

Insulin-like growth factor binding protein 7 (IGFBP7) has a strong affinity to insulin. This study aimed to evaluate the relationship between IGFBP7 and complications among type 2 diabetes mellitus (T2DM) patients.

Design

A total of 1449 T2DM patients were selected from a cross-sectional study for disease management registered in the National Basic Public Health Service in Changshu, China, and further tested for their plasma IGFBP7 levels. Logistic regressions and Spearman's rank correlation analyses were used to explore the associations of IGFBP7 with diabetic complications and clinical characteristics, respectively.

Results

Among the 1449 included T2DM patients, 403 (27.81%) had complications. In patients with shorter duration (less than five years), the base 10 logarithms of IGFBP7 concentration were associated with T2DM complications, with an adjusted odds ratio (OR) of 2.41 [95% confidence interval (95%CI) = 1.06–5.48]; while in patients with longer duration (more than five years), plasma IGFBP7 levels were not associated with T2DM complications. Furthermore, in T2DM patients with shorter duration, those with two or more types of complications were more likely to have higher levels of IGFBP7.

Conclusion

IGFBP7 is positively associated with the risk of complication in T2DM patients with shorter duration.

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2 型糖尿病患者血浆 IGFBP7 水平与糖尿病并发症持续时间的关系

目的胰岛素样生长因子结合蛋白7（IGFBP7）与胰岛素有很强的亲和力。设计从常熟市国家基本公共卫生服务项目疾病管理横断面研究中选取 1449 例 T2DM 患者，进一步检测其血浆 IGFBP7 水平。结果在纳入的1449例T2DM患者中，403例（27.81%）有并发症。在病程较短（少于五年）的患者中，IGFBP7浓度的基10对数与T2DM并发症有关，调整后的比值比（OR）为2.41[95%置信区间（95%CI）=1.06-5.48]；而在病程较长（五年以上）的患者中，血浆IGFBP7水平与T2DM并发症无关。结论IGFBP7与病程较短的T2DM患者的并发症风险呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Growth Hormone & Igf Research 医学-内分泌学与代谢

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

57 days

期刊介绍： Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.