{"title":"Looking through the imaging perspective: the importance of imaging necrosis in glioma diagnosis and prognostic prediction - single centre experience.","authors":"Hui Ma, Shanmei Zeng, Dingxiang Xie, Wenting Zeng, Yingqian Huang, Liwei Mazu, Nengjin Zhu, Zhiyun Yang, Jianping Chu, Jing Zhao","doi":"10.2478/raon-2024-0014","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The aim of the study was to investigate the diagnostic value of imaging necrosis (Im<sub>necrosis</sub>) in grading, predict the genotype and prognosis of gliomas, and further assess tumor necrosis by dynamic contrast-enhanced MR perfusion imaging (DCE-MRI).</p><p><strong>Patients and methods: </strong>We retrospectively included 150 patients (104 males, mean age: 46 years old) pathologically proved as adult diffuse gliomas and all diagnosis was based on the 2021 WHO central nervous system (CNS) classification. The pathological necrosis (Pa<sub>necrosis</sub>) and gene mutation information were collected. All patients underwent conventional and DCE-MRI examinations and had been followed until May 31, 2021. The Im<sub>necrosis</sub> was determined by two experienced neuroradiologists. DCE-MRI derived metric maps have been post-processed, and the mean value of each metric in the tumor parenchyma, peritumoral and contralateral area were recorded.</p><p><strong>Results: </strong>There was a strong degree of inter-observer agreement in defining Im<sub>necrosis</sub> (Kappa = 0.668, p < 0.001) and a strong degree of agreement between Im<sub>necrosis</sub> and Pa<sub>necrosis</sub> (Kappa = 0.767, p < 0.001). Compared to low-grade gliomas, high-grade gliomas had more Im<sub>necrosis</sub> (85.37%, p < 0.001), and Im<sub>necrosis</sub> significantly increased with the grade of gliomas increasing. And Im<sub>necrosis</sub> was significantly more identified in <i>IDH</i>-wildtype, <i>1p19q</i>-non-codeletion, and <i>CDKN2A/B</i>-homozygous-deletion gliomas. Using multivariate Cox regression analysis, Im<sub>necrosis</sub> was an independent and unfavorable prognosis factor (Hazard Ratio = 2.113, p = 0.046) in gliomas. Additionally, extravascular extracellular volume fraction (<i>ve</i>) in tumor parenchyma derived from DCE-MRI demonstrated the highest diagnostic efficiency in identifying Pa<sub>necrosis</sub> and Im<sub>necrosis</sub> with high specificity (83.3% and 91.9%, respectively).</p><p><strong>Conclusions: </strong>Im<sub>necrosis</sub> can provide supplementary evidence beyond Pa<sub>necrosis</sub> in grading, predicting the genotype and prognosis of gliomas, and <i>ve</i> in tumor parenchyma can help to predict tumor necrosis with high specificity.</p>","PeriodicalId":21034,"journal":{"name":"Radiology and Oncology","volume":"58 1","pages":"23-32"},"PeriodicalIF":2.1000,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10878771/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiology and Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2478/raon-2024-0014","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The aim of the study was to investigate the diagnostic value of imaging necrosis (Imnecrosis) in grading, predict the genotype and prognosis of gliomas, and further assess tumor necrosis by dynamic contrast-enhanced MR perfusion imaging (DCE-MRI).
Patients and methods: We retrospectively included 150 patients (104 males, mean age: 46 years old) pathologically proved as adult diffuse gliomas and all diagnosis was based on the 2021 WHO central nervous system (CNS) classification. The pathological necrosis (Panecrosis) and gene mutation information were collected. All patients underwent conventional and DCE-MRI examinations and had been followed until May 31, 2021. The Imnecrosis was determined by two experienced neuroradiologists. DCE-MRI derived metric maps have been post-processed, and the mean value of each metric in the tumor parenchyma, peritumoral and contralateral area were recorded.
Results: There was a strong degree of inter-observer agreement in defining Imnecrosis (Kappa = 0.668, p < 0.001) and a strong degree of agreement between Imnecrosis and Panecrosis (Kappa = 0.767, p < 0.001). Compared to low-grade gliomas, high-grade gliomas had more Imnecrosis (85.37%, p < 0.001), and Imnecrosis significantly increased with the grade of gliomas increasing. And Imnecrosis was significantly more identified in IDH-wildtype, 1p19q-non-codeletion, and CDKN2A/B-homozygous-deletion gliomas. Using multivariate Cox regression analysis, Imnecrosis was an independent and unfavorable prognosis factor (Hazard Ratio = 2.113, p = 0.046) in gliomas. Additionally, extravascular extracellular volume fraction (ve) in tumor parenchyma derived from DCE-MRI demonstrated the highest diagnostic efficiency in identifying Panecrosis and Imnecrosis with high specificity (83.3% and 91.9%, respectively).
Conclusions: Imnecrosis can provide supplementary evidence beyond Panecrosis in grading, predicting the genotype and prognosis of gliomas, and ve in tumor parenchyma can help to predict tumor necrosis with high specificity.
期刊介绍：
Radiology and Oncology is a multidisciplinary journal devoted to the publishing original and high quality scientific papers and review articles, pertinent to diagnostic and interventional radiology, computerized tomography, magnetic resonance, ultrasound, nuclear medicine, radiotherapy, clinical and experimental oncology, radiobiology, medical physics and radiation protection. Therefore, the scope of the journal is to cover beside radiology the diagnostic and therapeutic aspects in oncology, which distinguishes it from other journals in the field.
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