Exploring rabbit as a nonrodent species for general toxicology studies.

IF 3.4 3区医学 Q2 TOXICOLOGY

Toxicological Sciences Pub Date : 2024-04-29 DOI:10.1093/toxsci/kfae022

Katie Sokolowski, Patricia V Turner, Elise Lewis, Ronald L Wange, Marie C Fortin

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Abstract

To avoid adverse events in humans, toxicity studies in nonclinical species have been the foundation of safety evaluation in the pharmaceutical industry. However, it is recognized that working with animals in research is a privilege, and conscientious use should always respect the 3Rs: replacement, reduction, and refinement. In the wake of the shortages in routine nonrodent species and considering that nonanimal methods are not yet sufficiently mature, the value of the rabbit as a nonrodent species is worth exploring. Historically used in vaccine, cosmetic, and medical device testing, the rabbit is seldom used today as a second species in pharmaceutical development, except for embryo-fetal development studies, ophthalmic therapeutics, some medical devices and implants, and vaccines. Although several factors affect the decision of species selection, including pharmacological relevance, pharmacokinetics, and ADME considerations, there are no perfect animal models. In this forum article, we bring together experts from veterinary medicine, industry, contract research organizations, and government to explore the pros and cons, residual concerns, and data gaps regarding the use of the rabbit for general toxicity testing.

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探索将兔子作为一般毒理学研究的非啮齿动物物种。

为了避免在人类身上发生不良事件，在非临床物种中进行毒性研究一直是制药业安全评估的基础。然而，人们认识到，在研究中使用动物是一种特权，应始终遵守 3R 原则：替代、减少和改进。在常规非啮齿动物物种短缺的情况下，考虑到非动物方法尚未足够成熟，兔子作为非啮齿动物物种的价值值得探讨。兔历来用于疫苗、化妆品和医疗器械测试，如今除了胚胎-胎儿发育研究、眼科治疗、某些医疗器械和植入物以及疫苗外，很少作为第二物种用于药物开发。影响物种选择的因素很多，包括药理相关性、药代动力学和 ADME 等方面的考虑，但没有完美的动物模型。在这篇论坛文章中，我们汇集了来自兽医学、工业界、合同研究组织和政府的专家，共同探讨使用家兔进行一般毒性试验的利弊、遗留问题和数据缺口。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicological Sciences 医学-毒理学

CiteScore

7.70

自引率

7.90%

发文量

118

审稿时长

1.5 months

期刊介绍： The mission of Toxicological Sciences, the official journal of the Society of Toxicology, is to publish a broad spectrum of impactful research in the field of toxicology. The primary focus of Toxicological Sciences is on original research articles. The journal also provides expert insight via contemporary and systematic reviews, as well as forum articles and editorial content that addresses important topics in the field. The scope of Toxicological Sciences is focused on a broad spectrum of impactful toxicological research that will advance the multidisciplinary field of toxicology ranging from basic research to model development and application, and decision making. Submissions will include diverse technologies and approaches including, but not limited to: bioinformatics and computational biology, biochemistry, exposure science, histopathology, mass spectrometry, molecular biology, population-based sciences, tissue and cell-based systems, and whole-animal studies. Integrative approaches that combine realistic exposure scenarios with impactful analyses that move the field forward are encouraged.