The potential immunomodulatory effect of levamisole in humans and farm animals.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-12-31 eCollection Date: 2023-12-01 DOI:10.5455/javar.2023.j717

Mohammad Hossein Gholami, Ali Rassouli, Sepideh Mirzaei, Farid Hashemi

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Abstract

This study conducted a literature review to investigate the immunomodulatory effect of levamisole in both humans and farm animals. The following procedure was followed for database searching: PubMed, Google Scholar, Web of Science, and Cochrane Library. All research works were updated to September 2022. The terms used in the literature search were included: ("levamisole" OR "immunity" OR "immune system") AND ("adjuvant" OR "fish" OR "poultry" OR "farm animal" OR "cattle" OR "sheep"). The current review enlightens the extensive potential of levamisole as an adjuvant immunotherapeutic agent and explains its divergent applications beyond its antiparasitic use as an adjuvant, dietary supplement, immunostimulant, antiviral, and anti-cancer drug in humans and farm animals. In the articles examined, various mechanisms have been proposed for levamisole immunoprotective effects, but hormonal alteration and stress hormone reduction are indicated as the main mechanisms in various animal species.

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左旋咪唑对人类和农场动物的潜在免疫调节作用。

本研究进行了文献综述，以调查左旋咪唑对人类和农场动物的免疫调节作用。数据库检索程序如下：PubMed、Google Scholar、Web of Science 和 Cochrane Library。所有研究成果均更新至 2022 年 9 月。文献检索中使用的术语包括(左旋咪唑 "或 "免疫 "或 "免疫系统"）和（"佐剂 "或 "鱼 "或 "家禽 "或 "农场动物 "或 "牛 "或 "羊"）。本综述揭示了左旋咪唑作为一种佐剂免疫治疗剂的广泛潜力，并解释了其在人类和农场动物中除作为佐剂、膳食补充剂、免疫刺激剂、抗病毒剂和抗癌药物用于抗寄生虫外的不同应用。在所研究的文章中，提出了左旋咪唑免疫保护作用的各种机制，但在各种动物物种中，激素改变和应激激素减少被认为是主要机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.