Immunogenicity of ferroptosis in cancer: a matter of context?

IF 14.3 1区 医学 Q1 ONCOLOGY
Trends in cancer Pub Date : 2024-05-01 Epub Date: 2024-02-16 DOI:10.1016/j.trecan.2024.01.013
Elena Catanzaro, Robin Demuynck, Faye Naessens, Lorenzo Galluzzi, Dmitri V Krysko
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引用次数: 0

Abstract

Ferroptosis is a variant of regulated cell death (RCD) elicited by an imbalance of cellular redox homeostasis that culminates with extensive lipid peroxidation and rapid plasma membrane breakdown. Since other necrotic forms of RCD, such as necroptosis, are highly immunogenic, ferroptosis inducers have attracted considerable attention as potential tools to selectively kill malignant cells while eliciting therapeutically relevant tumor-targeting immune responses. However, rather than being consistently immunogenic, ferroptosis mediates context-dependent effects on anticancer immunity. The inability of ferroptotic cancer cells to elicit adaptive immune responses may arise from contextual deficiencies in intrinsic aspects of the process, such as adjuvanticity and antigenicity, or from microenvironmental defects imposed by ferroptotic cancer cells themselves or elicited by the induction of ferroptosis in immune cells.

癌症中铁蛋白沉积的免疫原性:背景问题?
铁中毒是调节性细胞死亡(RCD)的一种变体,由细胞氧化还原平衡失调引起,最终导致大量脂质过氧化和质膜迅速破裂。由于其他坏死形式的 RCD(如坏死)具有很高的免疫原性,因此铁变态反应诱导剂作为选择性杀死恶性细胞的潜在工具,同时诱发治疗相关的肿瘤靶向免疫反应,引起了广泛关注。然而,铁变态反应并不具有持续的免疫原性,而是根据具体情况对抗癌免疫产生影响。铁凋亡癌细胞无法诱导适应性免疫反应可能是由于该过程内在方面(如佐剂性和抗原性)的环境缺陷,也可能是由于铁凋亡癌细胞本身造成的微环境缺陷或诱导免疫细胞铁凋亡所引起的微环境缺陷。
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来源期刊
Trends in cancer
Trends in cancer Medicine-Oncology
CiteScore
28.50
自引率
0.50%
发文量
138
期刊介绍: Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.
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