Unique quinoline orientations shape the molecular recognition of modified aptamer to sclerostin to facilitate enhancing its binding affinity and bone anabolic potential

Amu Gubu, Yuan Ma, Sifan Yu, Huarui Zhang, Zefeng Chen, Shuaijian Ni, Razack Abdullah, Huan Xiao, Yihao Zhang, Hong Dai, Hang Luo, Yuanyuan Yu, Luyao Wang, Hewen Jiang, Ning Zhang, Yuan Tian, Haitian Li, Aiping Lu, Baoting Zhang, Ge Zhang
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独特的喹啉取向形成了修饰过的适配体对硬骨蛋白的分子识别,有助于增强其结合亲和力和骨同化潜力
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