Application of metal organic frameworks-based functional composite scaffolds in tissue engineering

IF 5.6 1区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Regenerative Biomaterials Pub Date : 2024-02-01 DOI:10.1093/rb/rbae009

Xinlei Yao, Xinran Chen, Yu Sun, Pengxiang Yang, Xiaosong Gu, Xiu Dai

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引用次数: 0

Abstract

With the rapid development of materials science and tissue engineering, a variety of biomaterials have been used to construct tissue engineering scaffolds. Due to the performance limitations of single materials, functional composite biomaterials have attracted great attention as tools to improve the effectiveness of biological scaffolds for tissue repair. In recent years, metal organic frameworks (MOFs) have shown great promise for application in tissue engineering because of their high specific surface area, high porosity, high biocompatibility, appropriate environmental sensitivities and other advantages. This review introduces methods for the construction of MOFs-based functional composite scaffolds and describes the specific functions and mechanisms of MOFs in repairing damaged tissue. The latest MOFs-based functional composites and their applications in different tissues are discussed. Finally, the challenges and future prospects of using MOFs-based composites in tissue engineering are summarized. The aim of this review is to show the great potential of MOFs-based functional composite materials in the field of tissue engineering and to stimulate further innovation in this promising area.

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基于金属有机框架的功能复合支架在组织工程中的应用

随着材料科学和组织工程学的快速发展，各种生物材料已被用于构建组织工程支架。由于单一材料性能的局限性，功能复合生物材料作为提高生物支架组织修复效果的工具备受关注。近年来，金属有机框架（MOFs）因其高比表面积、高孔隙率、高生物相容性、适当的环境敏感性和其他优点，在组织工程中的应用前景十分广阔。本综述介绍了构建基于 MOFs 的功能复合支架的方法，并阐述了 MOFs 在修复受损组织方面的具体功能和机制。还讨论了最新的基于 MOFs 的功能复合材料及其在不同组织中的应用。最后，总结了在组织工程中使用基于 MOFs 的复合材料所面临的挑战和未来前景。本综述旨在展示基于 MOFs 的功能复合材料在组织工程领域的巨大潜力，并激励人们在这一前景广阔的领域进一步创新。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regenerative Biomaterials Materials Science-Biomaterials

CiteScore

7.90

自引率

16.40%

发文量

审稿时长

10 weeks

期刊介绍： Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.