Trabecular bone score in obese patients with and without diabetes

Abstract

The link between obesity, diabetes and bone metabolism is quite complex and not entirely clear. Although many clinical and epidemiological studies demonstrate that obesity enhances bone mineral density, its effect on bone microarchitecture is uncertain. The objective of this study was to examine the bone microarchitecture in obese patients with and without diabetes. The study included 119 individuals with ages from 30 to 50. Participants were divided into three groups: obese patients, obese diabetic patients, and a healthy control group. Results showed that obesity has a positive effect on trabecular bone score (TBS). Diabetes and obesity have a significant interactive impact on bone microarchitecture (TBS). Furthermore, HbA1c influences TBS in both obese diabetic patients and obese non-diabetic subjects. In contrast to the majority of studies, we found that obesity positively influenced TBS. TBS was inversely related to HbA1c levels in obese type 2 diabetics. Diabetes and obesity have a significant interactive impact on bone structure, in particular on bone microarchitecture.