Production and radiochemical separation of 68Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron

IF 1.4 3区 化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR
S. Chattopadhyay, Samarjit Singha, Shayantani Ash, Luna Barua, Devaraj G. Mahesh, Sujata SahaDas, Madhusmita, Md. Nayer Alam, Umesh Kumar, Suprakash Roy, Prosenjit Dhang, S. Dey
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引用次数: 0

Abstract

Gallium-68 [t 1/2: 67.7 min, β+ (89 %)] has application in PET imaging mainly for prostate cancer and neuroendocrine tumours. Gallium-68 is generally obtained from a 68Ge/68Ga generator. It is therefore an important task to prepare 68Ge (t 1/2 = 271 days) radiochemical for the manufacture of 68Ge/68Ga generator to cater for the needs of various nuclear medicine centres. Germanium-68 has been produced successfully after irradiation of indigenously developed Ga–Ni targets in a 30 MeV cyclotron and chemical processing of the irradiated targets using an indigenous semi-automated module. The Ga–Ni targets were prepared by an electroplating method. The 68Ge has been radiochemically separated from irradiated Ga–Ni targets using Sephadex G-25 column chromatography. The chemical separation yield and radionuclidic purity of 68Ge were about 70 % (n = 3) and about 98.3 % (n = 3), respectively.
在 30 MeV 回旋加速器中从辐照镓镍合金靶中生产 68Ge 并进行放射化学分离
镓-68[t 1/2:67.7 分钟,β+ (89 %)]主要用于前列腺癌和神经内分泌肿瘤的 PET 成像。镓-68 通常从 68Ge/68Ga 发生器中获得。因此,为生产 68Ge/68Ga 发生器制备 68Ge(t 1/2 = 271 天)放射化学物质以满足各核医学中心的需求是一项重要任务。在 30 兆电子伏回旋加速器中对本国开发的镓-镍靶进行辐照,并使用本国的半自动化模块对辐照靶进行化学处理后,锗-68 已成功生产。镓镍靶是用电镀法制备的。使用 Sephadex G-25 柱色谱法从辐照镓-镍靶中放射性化学分离出 68Ge。68Ge 的化学分离收率和放射性核素纯度分别约为 70%(n = 3)和 98.3%(n = 3)。
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来源期刊
Radiochimica Acta
Radiochimica Acta 化学-核科学技术
CiteScore
2.90
自引率
16.70%
发文量
78
审稿时长
6 months
期刊介绍: Radiochimica Acta publishes manuscripts encompassing chemical aspects of nuclear science and technology.
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