Production and radiochemical separation of 68Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-02-14 DOI:10.1515/ract-2023-0195

S. Chattopadhyay, Samarjit Singha, Shayantani Ash, Luna Barua, Devaraj G. Mahesh, Sujata SahaDas, Madhusmita, Md. Nayer Alam, Umesh Kumar, Suprakash Roy, Prosenjit Dhang, S. Dey

引用次数: 0

Abstract

Gallium-68 [t 1/2: 67.7 min, β+ (89 %)] has application in PET imaging mainly for prostate cancer and neuroendocrine tumours. Gallium-68 is generally obtained from a 68Ge/68Ga generator. It is therefore an important task to prepare 68Ge (t 1/2 = 271 days) radiochemical for the manufacture of 68Ge/68Ga generator to cater for the needs of various nuclear medicine centres. Germanium-68 has been produced successfully after irradiation of indigenously developed Ga–Ni targets in a 30 MeV cyclotron and chemical processing of the irradiated targets using an indigenous semi-automated module. The Ga–Ni targets were prepared by an electroplating method. The 68Ge has been radiochemically separated from irradiated Ga–Ni targets using Sephadex G-25 column chromatography. The chemical separation yield and radionuclidic purity of 68Ge were about 70 % (n = 3) and about 98.3 % (n = 3), respectively.

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在 30 MeV 回旋加速器中从辐照镓镍合金靶中生产 68Ge 并进行放射化学分离

镓-68[t 1/2：67.7 分钟，β+ (89 %)]主要用于前列腺癌和神经内分泌肿瘤的 PET 成像。镓-68 通常从 68Ge/68Ga 发生器中获得。因此，为生产 68Ge/68Ga 发生器制备 68Ge（t 1/2 = 271 天）放射化学物质以满足各核医学中心的需求是一项重要任务。在 30 兆电子伏回旋加速器中对本国开发的镓-镍靶进行辐照，并使用本国的半自动化模块对辐照靶进行化学处理后，锗-68 已成功生产。镓镍靶是用电镀法制备的。使用 Sephadex G-25 柱色谱法从辐照镓-镍靶中放射性化学分离出 68Ge。68Ge 的化学分离收率和放射性核素纯度分别约为 70%（n = 3）和 98.3%（n = 3）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

Production and radiochemical separation of 68Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron

Abstract

Production and radiochemical separation of 68Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron