Influence of multimorbidity on the risk of events in men with chronic coronary artery disease after myocardial infarction and percutaneous coronary intervention

Q3 Social Sciences

Cardiovascular Therapy and Prevention Pub Date : 2024-02-08 DOI:10.15829/1728-8800-2023-3883

D. Dedov, V. P. Mazaev, A. N. Kovalchuk, A. Komkov, S. Ryazanova

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引用次数: 0

Abstract

Aim. To study the effect of multimorbidity on the risk of cardiovascular events (CVEs) in men with chronic coronary artery disease (CAD) after myocardial infarction (MI) and percutaneous coronary intervention (PCI).Material and methods. A total of 101 men with chronic CAD after MI and PCI were included in the study (mean age 60,5±6,1 years). Of these, taking into account the non-inclusion criteria and consent to examination, 2 following groups were formed: first (n=39) — men without CVEs; 2nd (n=39) — men with CVEs. In both groups, we studied the detection rate of grade I hypertension (HTN), class I obesity, hypercholesterolemia (HCE), and type 2 diabetes (T2D). The influence of HTN, obesity, HCE, and T2D on the risk of cardiovascular events was analyzed based on the calculation of contingency tables and Pearson's χ2, as well as odds ratios (OR) with 95,0% confidence intervals (CI). The follow-up period for patients averaged 3,6±0,5 years.Results. In men of group 2, compared with group 1 patients, grade I HTN, class I obesity, HCE were diagnosed more often in 1,3 (p=0,044), 1,4 (p=0,047), 1,2 (p=0,059) times, respectively. An increase in the risk of CVEs in men with chronic CAD, who underwent MI and PCI was associated with the detection of grade I HTN, class I obesity, HCE — OR 2,44 (CI: 1,88-6,75), OR 1,78 (CI: 1,56-4,62), OR 1,37 (CI: 1,11-4,17), respectively.Conclusion. Thus, the detection rate of grade I HTN, class I obesity and HCE in men with chronic CAD and CVEs at long-term follow-up after MI and PCI was significantly higher compared to patients with chronic CAD without CVEs after PCI. At the same time, the detection of grade I HTN, class I obesity and HCE were associated with an increased risk of cardiovascular events.

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多病对慢性冠状动脉疾病男性患者在心肌梗死和经皮冠状动脉介入治疗后发生事件风险的影响

目的研究心肌梗死（MI）和经皮冠状动脉介入治疗（PCI）后患有慢性冠状动脉疾病（CAD）的男性中，多病对心血管事件（CVE）风险的影响。研究共纳入 101 名心肌梗死和经皮冠状动脉介入治疗后患有慢性冠状动脉疾病的男性（平均年龄为 60.5±6.1 岁）。其中，考虑到非纳入标准和同意检查的情况，分为以下两组：第一组（39 人）--无 CVE 的男性；第二组（39 人）--有 CVE 的男性。在这两组中，我们研究了 I 级高血压（HTN）、I 级肥胖、高胆固醇血症（HCE）和 2 型糖尿病（T2D）的检出率。高血压、肥胖、高胆固醇血症和 T2D 对心血管事件风险的影响是通过计算或然率表和 Pearson's χ2 以及带有 95.0% 置信区间 (CI) 的几率比 (OR) 进行分析的。患者的随访时间平均为 3.6±0.5 年。与第一组患者相比，第二组男性患者中，I级高血压、I级肥胖、HCE的诊断率分别为1.3（P=0.044）、1.4（P=0.047）、1.2（P=0.059）倍。接受心肌梗死和PCI手术的男性慢性CAD患者发生CVE的风险增加与I级高血压、I级肥胖和HCE的检出率有关，OR值分别为2,44（CI：1,88-6,75）、OR值分别为1,78（CI：1,56-4,62）、OR值分别为1,37（CI：1,11-4,17）。因此，在 MI 和 PCI 后的长期随访中，慢性 CAD 和 CVE 男性患者的 I 级高血压、I 级肥胖和 HCE 的检出率明显高于 PCI 后无 CVE 的慢性 CAD 患者。同时，I级高血压、I级肥胖和HCE的检出与心血管事件风险的增加有关。

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来源期刊

Cardiovascular Therapy and Prevention Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.70

自引率

0.00%

发文量

155

审稿时长

6-12 weeks

期刊介绍： The most important objectives of the journal are: the generalization of scientific and practical achievements in the field of cardiology, increasing scientific and practical skills of cardiologists. The scientific concept of publication does the publication of modern achievements in the field of epidemiology, prevention and treatment of cardiovascular diseases, the results of research, national and international clinical trials. For publication in the journal are invited both domestic and foreign scientists and clinicians working in the field of cardiology, as well as doctors of other specialties. The magazine covers various issues in cardiology and related specialties. Each issue is prepared by Executive editor of the issue, a respected specialist in the field of epidemiology, prevention and treatment of cardiovascular diseases. The main focus of the publication — scientific articles on original research, the pharmacotherapy of cardiovascular disease, new diagnostic methods. All members of the group of authors should meet all four criteria of authorship set forth in the ICMJE recommendations: 1) concept and design development or data analysis and interpretation, and 2) manuscript justification or verification of critical intellectual content, and 3) final approval for publication of the manuscript, and 4) consent to be responsible for all aspects of the work, and assume that issues relating to the thoroughness and diligent execution of any part of the study submitted are duly investigated and resolved. Great importance the editors attached to the preparation of scientific papers by groups of authors at a high level, literacy, authors, and their ownership information, availability of research results not only to colleagues in Russia, but also abroad.