Carvacrol: A Prospective Gold Mine of New Drug Discovery and Development

Bangladesh Pharmaceutical Journal Pub Date : 2024-02-11 DOI:10.3329/bpj.v27i1.71154

A. Zaman, Suriya Akter Shampa, Nazim Uddin Ahmed, Md Jasim Uddin, Md Al Amin Miah, Shabiba Parvin Shandhi, Bakul Akter, Safaet Alam

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Abstract

Carvacrol, a widely extracted monoterpenoid phenol from an abundant number of aromatic plant species including thyme and oregano. At present, carvacrol is being utilized in low concentrations as a preservative and food flavoring agent, in addition to serving as a fragrance element in cosmetic formulations. A great deal of study has been done in recent years as an effort to determine the biological effects of carvacrol for possible therapeutic application. Carvacrol has been identified to have a vast range of biological and pharmacological characteristics which include antidiabetic, antimicrobial, antiinflammatory, anti-obesity, antitumor, hepatoprotective, gastroprotective, and neuroprotective effects based on both in vitro and in vivo experiments. The main objective of this review is to assess current understanding of carvacrol's pharmacological impacts as well as its biosynthesis and plant sources in order to potentially inform the future researchers. It can be postulated that upon extensive research, this noteworthy bioactive phytochemical can be a very promising source of next generation drug development. Bangladesh Pharmaceutical Journal 27(1): 116-125, 2024 (January)

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香芹酚：新药发现和开发的前瞻性金矿

香芹酚是从百里香和牛至等大量芳香植物中广泛提取的单萜酚类。目前，除了作为化妆品配方中的香料成分外，香芹酚还被用作低浓度防腐剂和食品调味剂。近年来，人们对香芹酚的生物效应进行了大量研究，以确定其可能的治疗用途。根据体外和体内实验，发现香芹酚具有多种生物和药理特性，包括抗糖尿病、抗菌、抗炎、抗肥胖、抗肿瘤、保肝、保胃和神经保护作用。本综述的主要目的是评估目前对香芹酚的药理作用及其生物合成和植物来源的认识，以便为未来的研究人员提供参考。可以推测，经过广泛研究，这种值得注意的生物活性植物化学物质将成为下一代药物开发的一个非常有前景的来源：孟加拉制药杂志》27（1）：116-125，2024 年（1 月

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Bangladesh Pharmaceutical Journal

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