Extra-intestinal salmonellosis in a tertiary care centre in South India

IF 1.3 Q4 MICROBIOLOGY

Iranian Journal of Microbiology Pub Date : 2024-02-12 DOI:10.18502/ijm.v16i1.14885

V. Ganesan, Shyamala Ravikoti, R. Sundaramurthy, M. Raghavan, Rajendran Tiruvanamalai

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Abstract

Background and Objectives: Extra-intestinal salmonellosis is associated with higher case fatality and is underestimated in the developing countries like India. Here we present a case series of bacteriologically proven extra-intestinal salmonellosis managed at our institute over the past two years. Materials and Methods: Retrospective analysis of bacteriologically proven extra-intestinal salmonellosis over two years between January 2020 to December 2021 was carried out. Medical records were reviewed for site of infection, evidence of any underlying or predisposing illnesses and antimicrobial susceptibility report. Results: Eight patients were diagnosed with extra-intestinal salmonellosis. Male to female ratio was 3:1. Mean age was 44 years. Four were typhoidal and four were nontyphoidal Salmonellae. The extra-intestinal sites involved were purulent aspi- rates from scrotum, caecum, perianal region, intraperitoneal collection, synovium, and urine. Predisposing factors include chronic myeloid leukemia, HIV and gastric malignancy. All deep seated abscess required surgical intervention. All typhoidal Salmonella (n=4) were sensitive to cotrimoxazole, ampicillin, ceftriaxone. Among nontyphoidal Salmonella, one was resis- tant to cotrimoxazole; two were resistant to ampicillin, ceftriaxone and three resistant to ciprofloxacin. Conclusion: The diagnosis of extra-intestinal salmonellosis requires a high degree of clinical suspicion and should be in- cluded in the differential diagnosis in patients with deep-seated abscesses.

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印度南部一家三级医疗中心的肠外沙门氏菌病

背景和目的：肠外沙门氏菌病死亡率较高，在印度等发展中国家被低估。在此，我们介绍了过去两年中我院收治的经细菌学证实的肠外沙门氏菌病病例系列。材料和方法：对 2020 年 1 月至 2021 年 12 月两年内经细菌学证实的肠外沙门氏菌病进行回顾性分析。对病历进行审查，以了解感染部位、任何潜在或易感疾病的证据以及抗菌药物敏感性报告。结果八名患者被诊断为肠道外沙门氏菌病。男女比例为 3:1。平均年龄为 44 岁。四例为伤寒型沙门氏菌，四例为非伤寒型沙门氏菌。肠外感染部位包括阴囊、盲肠、肛周、腹腔、滑膜和尿液。诱发因素包括慢性髓性白血病、艾滋病毒和胃部恶性肿瘤。所有深部脓肿都需要手术治疗。所有伤寒沙门氏菌（4 个）都对复方新诺明、氨苄西林和头孢曲松敏感。在非伤寒沙门氏菌中，1 例对复方新诺明耐药，2 例对氨苄西林和头孢曲松耐药，3 例对环丙沙星耐药。结论肠外沙门氏菌病的诊断需要临床高度怀疑，并应纳入深部脓肿患者的鉴别诊断中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Microbiology MICROBIOLOGY-

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Microbiology (IJM) is an international, multi-disciplinary, peer-reviewed journal that provides rapid publication of the most advanced scientific research in the areas of basic and applied research on bacteria and other micro-organisms, including bacteria, viruses, yeasts, fungi, microalgae, and protozoa concerning the development of tools for diagnosis and disease control, epidemiology, antimicrobial agents, clinical microbiology, immunology, Genetics, Genomics and Molecular Biology. Contributions may be in the form of original research papers, review articles, short communications, case reports, technical reports, and letters to the Editor. Research findings must be novel and the original data must be available for review by the Editors, if necessary. Studies that are preliminary, of weak originality or merely descriptive as well as negative results are not appropriate for the journal. Papers considered for publication must be unpublished work (except in an abstract form) that is not under consideration for publication anywhere else, and all co-authors should have agreed to the submission. Manuscripts should be written in English.