Association study of polymorphisms in miRNA-1687 with growth traits of chickens

IF 0.7 4区农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE

South African Journal of Animal Science Pub Date : 2024-02-15 DOI:10.4314/sajas.v53i3.09

J. Z. Shi, Y. W. Wang, T. J. Wang, J. Ji, G. R. Sun, L. G. Yao

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引用次数: 0

Abstract

Polymorphisms within microRNAs can lead to phenotypic variations in organisms. The purpose of this research was to investigate the potential impact of the pre-miR-1687 single nucleotide polymorphism (SNP) on the economic characteristics of weight and body size in chickens. The SNP was genotyped using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. A linear mixed model was utilized to analyse the associations between the SNP and chicken body size and growth traits. The SNP in the pre-miR-1687 gene was correlated with F2 chicken body weight (BW) at birth and at 4, 6, 8, and 10 weeks of age. The SNP in the gga-miR-1687 gene was correlated with shank length, shank girth, pectoral angle (at 4 weeks), and pelvic breadth (at 8 weeks). Different BW genotypes were observed in the studied flocks. The changes in the secondary structure of pre-miR-1687 and in the free energy values were estimated using online M-fold software. The results serve as a helpful resource for subsequent research on the mechanisms and functions of miRNAs. In addition, the study provides a credible basis for the application of biomolecular technology in poultry breeding.

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miRNA-1687 多态性与鸡生长特征的关联研究

微RNA的多态性可导致生物的表型变异。本研究旨在调查前miR-1687单核苷酸多态性（SNP）对鸡的体重和体型等经济特征的潜在影响。该 SNP 采用基质辅助激光解吸/电离飞行时间质谱法进行基因分型。利用线性混合模型分析了SNP与鸡体型和生长性状之间的关联。pre-miR-1687基因中的SNP与F2鸡出生时、4周龄、6周龄、8周龄和10周龄时的体重（BW）相关。gga-miR-1687 基因中的 SNP 与胫长、胫围、胸角（4 周龄）和骨盆宽度（8 周龄）相关。在研究的鸡群中观察到了不同的体重基因型。使用在线 M-fold 软件估算了前 miR-1687 二级结构和自由能值的变化。研究结果为后续研究 miRNA 的机制和功能提供了有用的资源。此外，该研究还为生物分子技术在家禽育种中的应用提供了可靠的依据。

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来源期刊

South African Journal of Animal Science 农林科学-奶制品与动物科学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： The South African Journal of Animal Science is an open access, peer-reviewed journal for publication of original scientific articles and reviews in the field of animal science. The journal publishes reports of research dealing with production of farmed animal species (cattle, sheep, goats, pigs, horses, poultry and ostriches), as well as pertinent aspects of research on aquatic and wildlife species. Disciplines covered nutrition, genetics, physiology, and production systems. Systematic research on animal products, behaviour, and welfare are also invited. Rigorous testing of well-specified hypotheses is expected.