Neurosteroids: A potential target for neuropsychiatric disorders

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-02-17 DOI:10.1016/j.jsbmb.2024.106485

Mengyu Wang , Suwan Hu , Xinghuo Fu, Huixuan Zhou, Siqi Yang, Chun Yang

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Abstract

Neurosteroids are steroids produced by endocrine glands and subsequently entering the brain, and also include steroids synthesis in the brain. It has been widely known that neurosteroids influence many neurological functions, including neuronal signaling, synaptic adaptations, and neuroprotective effects. In addition, abnormality in the synthesis and function of neurosteroids has been closely linked to neuropsychiatric disorders, such as Alzheimer's disease (AD), schizophrenia (SZ), and epilepsy. Given their important role in brain pathophysiology and disorders, neurosteroids offer potential therapeutic targets for a variety of neuropsychiatric diseases, and that therapeutic strategies targeting neurosteroids probably exert beneficial effects. We therefore summarized the role of neurosteroids in brain physiology and neuropsychiatric disorders, and introduced the recent findings of synthetic neurosteroid analogues for potential treatment of neuropsychiatric disorders, thereby providing insights for further research in the future.

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神经类固醇：神经精神疾病的潜在治疗目标

神经类固醇是由内分泌腺分泌并随后进入大脑的类固醇，也包括在大脑中合成的类固醇。众所周知，神经类固醇会影响多种神经功能，包括神经元信号传导、突触适应和神经保护作用。此外，神经类固醇的合成和功能异常与阿尔茨海默病（AD）、精神分裂症（SZ）和癫痫等神经精神疾病密切相关。鉴于神经类固醇在大脑病理生理学和疾病中的重要作用，神经类固醇为各种神经精神疾病提供了潜在的治疗靶点，而且针对神经类固醇的治疗策略很可能会产生有益的效果。因此，我们总结了神经类固醇在脑生理学和神经精神疾病中的作用，并介绍了合成神经类固醇类似物用于治疗神经精神疾病的最新研究成果，从而为今后的进一步研究提供启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464