Recent Advance in the Study on 5-Formylcytosine (f5C) RNA Modification

IF 2.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Israel Journal of Chemistry Pub Date : 2024-02-12 DOI:10.1002/ijch.202300178

Xin Wang, Dr. Xiao-Yang Jin, Prof. Dr. Liang Cheng

引用次数: 0

Abstract

The widespread involvement of 5-formylcytosine f⁵C RNA in gene function regulation and its impact on crucial life processes like cell differentiation, embryonic development, and disease development underscores the significance of detecting this specific base modification. This detection holds great importance for basic epigenetics research and the early diagnosis and pathogenesis research of various diseases. This review aims to summarize recent research progress in f⁵C detection methods using selective chemical labeling, with the hope of aiding future research endeavors.

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5-甲酰基胞嘧啶 (f5C) RNA 修饰研究的最新进展

5-甲酰基胞嘧啶 f5C RNA 广泛参与基因功能调控，并对细胞分化、胚胎发育和疾病发展等关键生命过程产生影响，因此检测这种特定碱基修饰意义重大。这种检测对表观遗传学基础研究以及各种疾病的早期诊断和发病机制研究具有重要意义。本综述旨在总结利用选择性化学标记法检测 f5C 的最新研究进展，希望对未来的研究工作有所帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Israel Journal of Chemistry 化学-化学综合

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The fledgling State of Israel began to publish its scientific activity in 1951 under the general heading of Bulletin of the Research Council of Israel, which quickly split into sections to accommodate various fields in the growing academic community. In 1963, the Bulletin ceased publication and independent journals were born, with Section A becoming the new Israel Journal of Chemistry. The Israel Journal of Chemistry is the official journal of the Israel Chemical Society. Effective from Volume 50 (2010) it is published by Wiley-VCH. The Israel Journal of Chemistry is an international and peer-reviewed publication forum for Special Issues on timely research topics in all fields of chemistry: from biochemistry through organic and inorganic chemistry to polymer, physical and theoretical chemistry, including all interdisciplinary topics. Each topical issue is edited by one or several Guest Editors and primarily contains invited Review articles. Communications and Full Papers may be published occasionally, if they fit with the quality standards of the journal. The publication language is English and the journal is published twelve times a year.