Effect of Temperature on the Protective Properties of the Escherichia coli DNA-Binding Protein Dps under Desiccation Stress

IF 1.3 4区生物学 Q4 MICROBIOLOGY

Microbiology Pub Date : 2024-02-07 DOI:10.1134/s0026261723603640

N. G. Loiko, E. V. Tereshkin, V. V. Kovalenko, Y. F. Krupyanskii, K. B. Tereshkina

引用次数: 0

Abstract—

Adaptive mechanisms allow bacteria to survive even under extreme desiccation, which they face both in the natural environment and in biotechnological processes. The DNA-binding protein Dps plays an important role in this process. In the present work, we revealed the protective properties of the Dps protein under desiccation stress to depend on both the cultivation temperature and the temperature of the subsequent desiccation process. The experimental data obtained were successfully predicted by the calculations performed using modern classical molecular dynamics methods. The results of the study are important for applications in biotechnological production and microbial collections.

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温度对干燥胁迫下大肠杆菌 DNA 结合蛋白 Dps 保护特性的影响

摘要--适应机制使细菌在自然环境和生物技术过程中面临的极端干燥条件下也能生存。DNA 结合蛋白 Dps 在这一过程中发挥着重要作用。在本研究中，我们发现 Dps 蛋白在干燥压力下的保护特性取决于培养温度和随后干燥过程的温度。利用现代经典分子动力学方法进行的计算成功地预测了所获得的实验数据。研究结果对生物技术生产和微生物收集方面的应用具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiology 生物-微生物学

CiteScore

2.40

自引率

13.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Microbiology is an is an international peer reviewed journal that covers a wide range of problems in the areas of fundamental and applied microbiology. The journal publishes experimental and theoretical papers, reviews on modern trends in different fields of microbiological science, and short communications with descriptions of unusual observations. The journal welcomes manuscripts from all countries in the English or Russian language.