Oral Cancer: Past, present and future of NK cell-based cancer immunotherapy

IF 0.8 4区医学 Q4 IMMUNOLOGY

Critical Reviews in Immunology Pub Date : 2024-02-01 DOI:10.1615/critrevimmunol.2024052389

Kawaljit Kaur, Anahid Jewett

引用次数: 0

Abstract

Despite advancements in the field of cancer therapeutics the five-year survival rate remains low in oral cancer patients. There, the effective therapeutics are needed to control the disease. Also, several studies including ours have shown severely suppressed function and number of NK cells in oral cancer patients. In this review, we discuss the approach to inhibit the tumor growth and metastasis by direct killing or NK cell-mediated tumor differentiation. This review also provides the overview on supercharging NK cells using osteoclasts and probiotic bacteria, and their efficacy as cancer immunotherapeutic in humanized-BLT mice.

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口腔癌基于 NK 细胞的癌症免疫疗法的过去、现在和未来

尽管癌症治疗领域取得了进步，但口腔癌患者的五年生存率仍然很低。因此，需要有效的治疗方法来控制病情。此外，包括我们在内的多项研究表明，口腔癌患者的 NK 细胞功能和数量受到严重抑制。在这篇综述中，我们讨论了通过直接杀伤或 NK 细胞介导的肿瘤分化来抑制肿瘤生长和转移的方法。本综述还概述了利用破骨细胞和益生菌增殖 NK 细胞的方法，以及它们在人源化 BLT 小鼠中作为癌症免疫疗法的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Immunology 医学-免疫学

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Immunology covers a broad spectrum of investigations at the genes, molecular, cellular, organ and system levels to reveal defense mechanisms against pathogens as well as protection against tumors and autoimmune diseases. The great advances in immunology in recent years make this field one of the most dynamic and rapidly growing in medical sciences. Critical ReviewsTM in Immunology (CRI) seeks to present a balanced overview of contemporary adaptive and innate immune responses related to autoimmunity, tumor, microbe, transplantation, neuroimmunology, immune regulation and immunotherapy from basic to translational aspects in health and disease. The articles that appear in CRI are mostly obtained by invitations to active investigators. But the journal will also consider proposals from the scientific community. Interested investigators should send their inquiries to the editor before submitting a manuscript.