The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project.

IF 2.7 3区医学 Q2 PSYCHIATRY

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2024-02-17 DOI:10.1177/10870547241226726

Sara Carucci, Alessandro Zuddas, Angelico Lampis, Kenneth K C Man, Carla Balia, Jan Buitelaar, Marina Danckaerts, Ralf W Dittmann, Federica Donno, Bruno Falissard, Antonella Gagliano, Peter Garas, Alexander Häge, Chris Hollis, Sarah K Inglis, Kerstin Konrad, Hanna Kovshoff, Elizabeth Liddle, Suzanne McCarthy, Antje Neubert, Peter Nagy, Eric Rosenthal, Edmund J S Sonuga-Barke, Ian C K Wong, Tobias Banaschewski, David Coghill

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引用次数: 0

Abstract

Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age.

Method: Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age.

Results: The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable.

Conclusion: Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.

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哌醋甲酯对多动症儿童和青少年青春期成熟和骨龄的影响：ADHD药物使用慢性影响（ADDUCE）项目的结果。

目的：哌醋甲酯（MPH）的短期安全性已得到广泛证实，但其长期安全性尚不明确。本研究旨在调查哌醋甲酯的安全性与青春期成熟的关系，并探讨对骨龄的监测：ADDUCE是一项为期两年的观察性纵向研究，其中包括三个平行组群（MPH组、无MPH组和非多动症对照组）。通过监测骨龄，对意大利的药物治疗多动症子样本进行了进一步评估：结果：用药组和未用药组的多动症患者在坦纳分期方面没有差异，这表明接受 MPH 治疗的患者性成熟延迟的风险并不高。监测骨龄的用药子样本在 24 个月后骨龄成熟略有加快，但其预测成年身高保持稳定：我们的研究结果表明，长期服用 MPH 不会对青春期成熟和生长产生安全隐患。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Attention Disorders PSYCHIATRY-

CiteScore

7.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Attention Disorders (JAD) focuses on basic and applied science concerning attention and related functions in children, adolescents, and adults. JAD publishes articles on diagnosis, comorbidity, neuropsychological functioning, psychopharmacology, and psychosocial issues. The journal also addresses practice, policy, and theory, as well as review articles, commentaries, in-depth analyses, empirical research articles, and case presentations or program evaluations.