Preoperative Attention/Memory Problem Affects the Quality of Life of Parkinson's Disease Patients after Deep Brain Stimulation: A Cohort Study.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Parkinson's Disease Pub Date : 2024-02-07 eCollection Date: 2024-01-01 DOI:10.1155/2024/3651705

Ying Gao, Jue Wang, Linbin Wang, Dianyou Li, Bomin Sun, Xian Qiu

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引用次数: 0

Abstract

Objectives: The aim of this study was to investigate the impact of nonmotor symptoms (NMS) on the quality of life (QoL) outcome after subthalamic nucleus deep brain stimulation (STN-DBS) at the 1-year follow-up.

Methods: Ninety-three patients diagnosed with Parkinson's disease (PD), who underwent subthalamic nucleus deep brain stimulation (STN-DBS) between April 2020 and August 2021, were included in this study. Demographic information was gathered through a self-designed questionnaire. The severity of both motor and non-motor symptoms, along with the quality of life (QoL), was assessed using the Unified Parkinson's Disease Rating Scale-III (UPDRS-III), Nonmotor Symptoms Scale (NMSS), and 8-item Parkinson's Disease Questionnaire (PDQ-8), respectively.

Results: Significant differences were observed in the UPDRS-III score, NMSS summary index (SI), and subscores of six domains (sleep/fatigue, mood/cognition, perceptual problems/hallucinations, attention/memory, urinary, and sexual function) between the baseline and the 6- and 12-month follow-ups. The correlation analysis revealed positive correlations between the preoperative NMSS SI and subscores of seven domains (cardiovascular, sleep/fatigue, mood/cognition, perceptual problems/hallucinations, attention/memory, gastrointestinal, and urinary) and ΔPDQ-8. Moreover, the preoperative PDQ-8 SI (β = 0.869, P < 0.001) and the preoperative attention/memory subscore (β = -0.154, P = 0.026) were predictive of the postsurgery improvement in quality of life (QoL).

Conclusion: Deep brain stimulation (DBS) led to an improvement in the patients' nonmotor symptoms (NMS) at the 1-year follow-up, along with a correlation observed between NMS and the patients' quality of life (QoL). Notably, the severity of preoperative attention/memory problems emerged as the most significant predictor of NMS influencing the QoL outcome after STN-DBS at the 1-year follow-up.

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术前注意力/记忆力问题影响深部脑刺激术后帕金森病患者的生活质量：一项队列研究

研究目的本研究旨在探讨眼下核深部脑刺激术（STN-DBS）后1年随访期间非运动症状（NMS）对生活质量（QoL）结果的影响：本研究纳入了在2020年4月至2021年8月期间接受脑下核深部刺激术（STN-DBS）的93名帕金森病（PD）患者。研究人员通过自行设计的问卷收集了患者的人口统计学信息。分别使用统一帕金森病评分量表-III（UPDRS-III）、非运动症状量表（NMSS）和8项帕金森病问卷（PDQ-8）评估运动症状和非运动症状的严重程度以及生活质量（QoL）：在UPDRS-III评分、NMSS汇总指数（SI）以及六个领域（睡眠/疲劳、情绪/认知、感知问题/幻觉、注意力/记忆力、泌尿系统和性功能）的子评分方面，基线值与6个月和12个月随访值之间存在显著差异。相关性分析显示，术前 NMSS SI 与七个领域（心血管、睡眠/疲劳、情绪/认知、感知问题/幻觉、注意力/记忆力、胃肠道和泌尿系统）的子分数和 ΔPDQ-8 之间存在正相关。此外，术前 PDQ-8 SI（β = 0.869，P < 0.001）和术前注意力/记忆力子分数（β = -0.154，P = 0.026）对术后生活质量（QoL）的改善具有预测作用：结论：脑深部刺激术（DBS）使患者的非运动症状（NMS）在1年随访时得到改善，同时观察到NMS与患者生活质量（QoL）之间存在相关性。值得注意的是，术前注意力/记忆力问题的严重程度是影响 STN-DBS 术后 1 年生活质量的 NMS 最重要的预测因素。

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来源期刊

Parkinson's Disease CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

3.10%

发文量

审稿时长

18 weeks

期刊介绍： Parkinson’s Disease is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the epidemiology, etiology, pathogenesis, genetics, cellular, molecular and neurophysiology, as well as the diagnosis and treatment of Parkinson’s disease.