Fourth Controlled Human Infection Model (CHIM) meeting – CHIMs in endemic countries, May 22–23, 2023

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-02-01 DOI:10.1016/j.biologicals.2024.101747

Melissa Kapulu , Lucinda Manda-Taylor , Shobana Balasingam , Gary Means , Mikal Ayiro Malungu , Philip Bejon , Primus Che Chi , Christopher Chiu , E. Chandler Church , Rodrigo Correa-Oliveira , Nicholas Day , Anna Durbin , Moses Egesa , Claudia Emerson , Kondwani Jambo , Roli Mathur , Wolfram Metzger , Noni Mumba , Winfred Nazziwa , Ally Olotu , Pieter Neels

{"title":"Fourth Controlled Human Infection Model (CHIM) meeting – CHIMs in endemic countries, May 22–23, 2023","authors":"Melissa Kapulu , Lucinda Manda-Taylor , Shobana Balasingam , Gary Means , Mikal Ayiro Malungu , Philip Bejon , Primus Che Chi , Christopher Chiu , E. Chandler Church , Rodrigo Correa-Oliveira , Nicholas Day , Anna Durbin , Moses Egesa , Claudia Emerson , Kondwani Jambo , Roli Mathur , Wolfram Metzger , Noni Mumba , Winfred Nazziwa , Ally Olotu , Pieter Neels","doi":"10.1016/j.biologicals.2024.101747","DOIUrl":null,"url":null,"abstract":"<div><p>Earlier meetings laid the foundations for Controlled Human Infection Models (CHIMs), also known as human challenge studies and human infection studies, including Good Manufacturing Practice (GMP) production of the challenge agent, CHIM ethics, environmental safety in CHIM, recruitment, community engagement, advertising and incentives, pre-existing immunity, and clinical, immunological, and microbiological endpoints. The fourth CHIM meeting focused on CHIM studies being conducted in endemic countries. Over the last ten years we have seen a vast expansion of the number of countries in Africa performing CHIM studies, as well as a growing number of different challenge organisms being used. Community and public engagement with assiduous ethical and regulatory oversight has been central to successful introductions and should be continued, in more community-led or community-driven models. Valuable initiatives for regulation of CHIMs have been undertaken but further capacity building remains essential.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1045105624000046/pdfft?md5=440fe4e1d3cece54f9e77639d77e127c&pid=1-s2.0-S1045105624000046-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1045105624000046","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Earlier meetings laid the foundations for Controlled Human Infection Models (CHIMs), also known as human challenge studies and human infection studies, including Good Manufacturing Practice (GMP) production of the challenge agent, CHIM ethics, environmental safety in CHIM, recruitment, community engagement, advertising and incentives, pre-existing immunity, and clinical, immunological, and microbiological endpoints. The fourth CHIM meeting focused on CHIM studies being conducted in endemic countries. Over the last ten years we have seen a vast expansion of the number of countries in Africa performing CHIM studies, as well as a growing number of different challenge organisms being used. Community and public engagement with assiduous ethical and regulatory oversight has been central to successful introductions and should be continued, in more community-led or community-driven models. Valuable initiatives for regulation of CHIMs have been undertaken but further capacity building remains essential.

查看原文本刊更多论文

第四次人类感染控制模型（CHIM）会议--流行国家的人类感染控制模型，2023 年 5 月 22-23 日。

前几次会议为受控人类感染模型（CHIM）（也称为人类挑战研究和人类感染研究）奠定了基础，包括挑战剂的良好生产规范（GMP）生产、CHIM 伦理学、CHIM 中的环境安全、招募、社区参与、广告和激励措施、原有免疫以及临床、免疫学和微生物学终点。第四次 CHIM 会议重点讨论了流行国家正在开展的 CHIM 研究。在过去十年中，我们看到非洲开展 CHIM 研究的国家数量大幅增加，所使用的不同挑战性生物体也越来越多。社区和公众的参与以及严格的伦理和监管监督一直是成功引进的关键，应继续采用更多社区主导或社区驱动的模式。对 CHIMs 的监管已经采取了有价值的举措，但进一步的能力建设仍然至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.