New users of anxiolytics and sedatives in Sweden—Drug type, doses, prescribers' characteristics, and psychiatric comorbidity in more than 750,000 patients

IF 2.4 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research Pub Date : 2024-02-13 DOI:10.1002/mpr.1998

Elin Dahlén, Carola Bardage, Paulina Tuvendal, Rickard Ljung

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引用次数: 0

Abstract

Objectives

Anxiety and sleep disorders are common in the population and anxiolytics and sedatives are widely used. Our aim was to describe the drug utilization of new users of anxiolytics and sedatives in adults including type of drug, doses, prescribers' characteristics, and psychiatric comorbidity.

Methods

A register-based cohort study of new users (18–64 years) of anxiolytics and sedatives in 2015–2019, free of any such drug 5 years prior to inclusion. The individuals were linked to national registers on dispensed drugs and recorded diagnoses.

Results

In total, 764,432 new users of anxiolytics and sedatives were identified, which corresponds to an incidence of 26/1000 inhabitants and year. The proportion of new users of benzodiazepines (including both anxiolytics and sedatives) decreased, whereas the proportion of sedative antihistamines and melatonin increased. The most common drug dispensed was hydroxizin (33%) followed by benzodiazepine related drugs (zopiclone and zolpidem; 20%), propiomazine (14%) and benzodiazepines (13%). The majority (68%) of the prescriptions were from primary care. Most new users were prescribed 1–30DDDs and 52% among women and 49% among men were dispensed their drug only once during the first year. Half of the new users had a previous comorbid psychiatric disorder.

Conclusions

The findings are well reflecting the recommendations in national guidelines.

Abstract Image

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瑞典抗焦虑药和镇静剂的新使用者--超过 75 万名患者的药物类型、剂量、处方者特征和精神病合并症。

目的：焦虑和睡眠障碍在人群中很常见，抗焦虑药和镇静剂被广泛使用。我们的目的是描述成人抗焦虑药和镇静剂新使用者的药物使用情况，包括药物类型、剂量、处方者特征和精神疾病合并症：对2015-2019年抗焦虑药和镇静剂的新使用者（18-64岁）进行基于登记的队列研究，在纳入前5年内未使用过任何此类药物。这些人与国家配药登记册和记录的诊断相关联：共发现 764 432 名抗焦虑药和镇静剂新使用者，相当于每年 26/1000 名居民的发病率。苯二氮卓类药物（包括抗焦虑药和镇静药）的新使用者比例有所下降，而镇静抗组胺药和褪黑素的比例有所上升。最常见的配药是羟嗪（33%），其次是苯二氮卓相关药物（佐匹克隆和唑吡坦；20%）、丙咪嗪（14%）和苯二氮卓（13%）。大部分处方（68%）来自初级保健。大多数新用药者的处方量为 1-30DDDs ，52% 的女性和 49% 的男性在第一年内只配药一次。半数新用药者曾合并有精神障碍：结论：研究结果很好地反映了国家指导方针的建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Methods in Psychiatric Research 医学-精神病学

CiteScore

5.20

自引率

6.50%

发文量

审稿时长

>12 weeks

期刊介绍： The International Journal of Methods in Psychiatric Research (MPR) publishes high-standard original research of a technical, methodological, experimental and clinical nature, contributing to the theory, methodology, practice and evaluation of mental and behavioural disorders. The journal targets in particular detailed methodological and design papers from major national and international multicentre studies. There is a close working relationship with the US National Institute of Mental Health, the World Health Organisation (WHO) Diagnostic Instruments Committees, as well as several other European and international organisations. MPR aims to publish rapidly articles of highest methodological quality in such areas as epidemiology, biostatistics, generics, psychopharmacology, psychology and the neurosciences. Articles informing about innovative and critical methodological, statistical and clinical issues, including nosology, can be submitted as regular papers and brief reports. Reviews are only occasionally accepted. MPR seeks to monitor, discuss, influence and improve the standards of mental health and behavioral neuroscience research by providing a platform for rapid publication of outstanding contributions. As a quarterly journal MPR is a major source of information and ideas and is an important medium for students, clinicians and researchers in psychiatry, clinical psychology, epidemiology and the allied disciplines in the mental health field.