Positive effects of anthocyanin-rich mulberry milk on mental health problems in the working population: an open-label study.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Nutrition Research and Practice Pub Date : 2024-02-01 Epub Date: 2024-01-16 DOI:10.4162/nrp.2024.18.1.110
Poonsri Rangseekajee, Nawanant Piyavhatkul, Jintanaporn Wattanathorn, Wipawee Thukham-Mee, Pongsatorn Paholpak
{"title":"Positive effects of anthocyanin-rich mulberry milk on mental health problems in the working population: an open-label study.","authors":"Poonsri Rangseekajee, Nawanant Piyavhatkul, Jintanaporn Wattanathorn, Wipawee Thukham-Mee, Pongsatorn Paholpak","doi":"10.4162/nrp.2024.18.1.110","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/objectives: </strong>Depression and anxiety are common mental health problems. Anthocyanins from berries might have an inhibitory effect on monoamine oxidase (MAO) enzymes and alleviate various mood and anxiety symptoms. This study examined the effects of a daily supplement of an anthocyanin-rich product on mental health problems.</p><p><strong>Subjects/methods: </strong>This study was a secondary analysis from a randomized, 6-week, open-label trial in 300 healthy participants aged 18-60 years who consumed 1 or 2 servings of anthocyanin-rich mulberry milk daily. The General Health Questionnaire-28 (GHQ-28) and Hospital Anxiety and Depression Scale (HADS) were used to monitor mental health problems. In addition, the saliva activity levels of MAO-A, MAO-B, and cortisol were examined at the baseline and after 6 weeks.</p><p><strong>Results: </strong>The total scores of the GHQ-28 and HADS and all their subscales decreased in both groups (all <i>P</i> < 0.05). The cortisol, MAO-A, and MAO-B activities decreased significantly (all <i>P</i> <0.05), but there were no significant differences between the groups (all <i>P</i> > 0.05). Significant correlations were noted between the decreased activity level of MAO-A enzyme and decreased scores from the GHQ-28 somatic subscale and the HADS depression subscale (all <i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>Daily consumption of anthocyanin-rich mulberry milk possibly improves mental health problems by reducing depressive and anxiety symptoms in the working population. The suppression of MAO-A activity is a possible underlying mechanism.</p><p><strong>Trial registration: </strong>Thai Clinical Trial Registration: #TCTR20201031002.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":"18 1","pages":"110-118"},"PeriodicalIF":2.0000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10861345/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Research and Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4162/nrp.2024.18.1.110","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/16 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0

Abstract

Background/objectives: Depression and anxiety are common mental health problems. Anthocyanins from berries might have an inhibitory effect on monoamine oxidase (MAO) enzymes and alleviate various mood and anxiety symptoms. This study examined the effects of a daily supplement of an anthocyanin-rich product on mental health problems.

Subjects/methods: This study was a secondary analysis from a randomized, 6-week, open-label trial in 300 healthy participants aged 18-60 years who consumed 1 or 2 servings of anthocyanin-rich mulberry milk daily. The General Health Questionnaire-28 (GHQ-28) and Hospital Anxiety and Depression Scale (HADS) were used to monitor mental health problems. In addition, the saliva activity levels of MAO-A, MAO-B, and cortisol were examined at the baseline and after 6 weeks.

Results: The total scores of the GHQ-28 and HADS and all their subscales decreased in both groups (all P < 0.05). The cortisol, MAO-A, and MAO-B activities decreased significantly (all P <0.05), but there were no significant differences between the groups (all P > 0.05). Significant correlations were noted between the decreased activity level of MAO-A enzyme and decreased scores from the GHQ-28 somatic subscale and the HADS depression subscale (all P < 0.05).

Conclusions: Daily consumption of anthocyanin-rich mulberry milk possibly improves mental health problems by reducing depressive and anxiety symptoms in the working population. The suppression of MAO-A activity is a possible underlying mechanism.

Trial registration: Thai Clinical Trial Registration: #TCTR20201031002.

富含花青素的桑葚牛奶对工作人群心理健康问题的积极影响:一项开放标签研究。
背景/目的:抑郁和焦虑是常见的心理健康问题。浆果中的花青素可能对单胺氧化酶(MAO)有抑制作用,并能缓解各种情绪和焦虑症状。本研究探讨了每天补充富含花青素的产品对心理健康问题的影响:本研究是一项为期 6 周的随机、开放标签试验的二次分析,300 名 18-60 岁的健康参与者每天饮用 1 或 2 份富含花青素的桑椹牛奶。研究采用了一般健康问卷-28(GHQ-28)和医院焦虑抑郁量表(HADS)来监测精神健康问题。此外,还检测了基线和 6 周后唾液中 MAO-A、MAO-B 和皮质醇的活性水平:结果:两组患者的 GHQ-28 和 HADS 总分及其所有分量表均有所下降(P 均小于 0.05)。皮质醇、MAO-A 和 MAO-B 活性显著下降(所有 P > 0.05)。MAO-A酶活性水平的降低与GHQ-28躯体分量表和HADS抑郁分量表得分的降低之间存在显著相关性(均为P < 0.05):结论:每天饮用富含花青素的桑葚牛奶可减少工作人群的抑郁和焦虑症状,从而改善心理健康问题。抑制 MAO-A 活性是可能的潜在机制:泰国临床试验注册:#TCTR20201031002。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Nutrition Research and Practice
Nutrition Research and Practice NUTRITION & DIETETICS-
CiteScore
3.50
自引率
4.20%
发文量
62
审稿时长
6-12 weeks
期刊介绍: Nutrition Research and Practice (NRP) is an official journal, jointly published by the Korean Nutrition Society and the Korean Society of Community Nutrition since 2007. The journal had been published quarterly at the initial stage and has been published bimonthly since 2010. NRP aims to stimulate research and practice across diverse areas of human nutrition. The Journal publishes peer-reviewed original manuscripts on nutrition biochemistry and metabolism, community nutrition, nutrition and disease management, nutritional epidemiology, nutrition education, foodservice management in the following categories: Original Research Articles, Notes, Communications, and Reviews. Reviews will be received by the invitation of the editors only. Statements made and opinions expressed in the manuscripts published in this Journal represent the views of authors and do not necessarily reflect the opinion of the Societies.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信