Human ILC2s can act as cytolytic killers

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2024-02-13 DOI:10.1038/s41577-024-01005-9

Maria Papatriantafyllou

引用次数: 0

查看原文本刊更多论文

人类 ILC2 可充当细胞溶解杀手

2型先天性淋巴细胞（ILC2s）具有促癌和抗癌功能。现在，Yu、Caligiuri及其同事发现，体外扩增的人类ILC2具有细胞毒性活性，当被收养转移到小鼠模型中时，可以杀死血液或实体肿瘤。扩增的人血源性ILC2与新鲜分离的细胞相似，但它们也表达IL-15受体CD122，并通过进一步上调细胞溶解分子颗粒酶B的分泌来对IL-15刺激做出反应，这需要自然杀伤（NK）细胞激活受体DNAM-1的表达、激酶AKT的激活和转录因子FOXO1的失活。在白血病小鼠模型中，DNAM-1配体CD155在癌细胞上的表达可通过减少DNAM-1在ILC2上的表达，促进癌细胞逃离被收养转移的ILC2。MEK抑制剂曲美替尼可降低癌细胞的CD155表达，恢复ILC2的细胞毒性。对人类 ILC2 重编程和扩增的进一步探索将确定它们是否适合作为癌症的细胞疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.

文献相关原料

公司名称	产品信息	采购帮参考价格