Frequency and Focus of in Vitro Studies of Microglia-Expressed Cytokines in Response to Viral Infection: A Systematic Review.

IF 3.6 4区 医学 Q3 CELL BIOLOGY
Diego A Barrios-González, Santiago Philibert-Rosas, Iris E Martínez-Juárez, Fernando Sotelo-Díaz, Verónica Rivas-Alonso, Julio Sotelo, Mario A Sebastián-Díaz
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Abstract

It is well known that as part of their response to infectious agents such as viruses, microglia transition from a quiescent state to an activated state that includes proinflammatory and anti-inflammatory phases; this behavior has been described through in vitro studies. However, recent in vivo studies on the function of microglia have questioned the two-phase paradigm; therefore, a change in the frequency of in vitro studies is expected. A systematic review was carried out to identify the microglial cytokine profile against viral infection that has been further evaluated through in vitro studies (pro-inflammatory or anti-inflammatory), along with analysis of its publication frequency over the years. For this review, 531 articles published in the English language were collected from PubMed, Web of Science, EBSCO and ResearchGate. Only 27 papers met the inclusion criteria for this systematic review. In total, 19 cytokines were evaluated in these studies, most of which are proinflammatory; the most common are IL-6, followed by TNF-α and IL-1β. It should be pointed out that half of the studies were published between 2015 and 2022 (raw data available in https://github.com/dadriba05/SystematicReview.git ). In this review, we identified that evaluation of pro-inflammatory cytokines released by microglia against viral infections has been performed more frequently than that of anti-inflammatory cytokines; additionally, a higher frequency of evaluation of the response of microglia cells to viral infection through in vitro studies from 2015 and beyond was noted.

Abstract Image

针对病毒感染的小胶质细胞表达细胞因子体外研究的频率和重点:系统综述。
众所周知,作为对病毒等传染性病原体反应的一部分,小胶质细胞会从静止状态过渡到活化状态,其中包括促炎和抗炎阶段;这种行为已通过体外研究进行了描述。然而,最近关于小胶质细胞功能的体内研究对两阶段范式提出了质疑;因此,体外研究的频率预计会发生变化。我们进行了一项系统性综述,以确定通过体外研究(促炎或抗炎)进一步评估的小胶质细胞抗病毒感染细胞因子特征,并分析其多年来的发表频率。本综述从 PubMed、Web of Science、EBSCO 和 ResearchGate 收集了 531 篇英文发表文章。只有 27 篇论文符合本系统综述的纳入标准。这些研究共评估了 19 种细胞因子,其中大部分是促炎因子;最常见的是 IL-6,其次是 TNF-α 和 IL-1β。需要指出的是,一半的研究发表于 2015 年至 2022 年之间(原始数据可在 https://github.com/dadriba05/SystematicReview.git 上获取)。在这篇综述中,我们发现对小胶质细胞针对病毒感染释放的促炎细胞因子进行评估的频率高于抗炎细胞因子;此外,我们还注意到,2015 年及以后通过体外研究对小胶质细胞对病毒感染的反应进行评估的频率更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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