Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2024-02-12 DOI:10.1007/s11418-023-01775-x

Yusuke Hirasawa, Ayaka Kase, Akie Okamoto, Keigo Suzuki, Mizuki Hiroki, Toshio Kaneda, Nahoko Uchiyama, Hiroshi Morita

引用次数: 0

Abstract

A new dimeric indole alkaloid, vincazalidine A consisting of an aspidosperma type and a modified iboga type with 1-azatricyclo ring system consisting of one azepane and two piperidine rings coupled with an oxazolidine ring was isolated from Catharanthus roseus, and the structure including absolute stereochemistry was elucidated on the basis of spectroscopic data as well as DP4 statistical analysis. Vincazalidine A induced G2 arrest and subsequent apoptosis in human lung carcinoma cell line, A549 cells.

Graphical abstract

Abstract Image

查看原文本刊更多论文

长春花苷 A，一种来自长春花的独特双吲哚生物碱。

从长春花中分离出了一种新的二聚吲哚生物碱--长春花苷A，它由一种表皮苷型和一种改良的伊波拉型组成，其1-氮杂三环环系由一个氮杂环和两个哌啶环以及一个恶唑烷环耦合而成，并根据光谱数据和DP4统计分析阐明了包括绝对立体化学在内的结构。长春花苷 A 诱导人肺癌细胞系 A549 细胞 G2 停滞并随后凋亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.