Pattern and value of Sperm DNA Fragmentation Index and its correlation with spermiogram in infertile South West Nigerian Men

Q3 Medicine

Morphologie Pub Date : 2024-02-08 DOI:10.1016/j.morpho.2024.100763

B.O. Ibitoye , F.O. Bashir , F.O. Ibitoye , O. Alabi , O.T. Olaniyan , P. Faduola , O.D. Bamisi , A.J. Ajibare , S.D. Omoseeye

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Abstract

Semen analysis has been used for a long time to assess male fertility due to its limitations sperm DNA fragmentation index (DFI), which describes the sperm DNA's condition, is an appropriate criterion for assessing male fertility. This study evaluated the pattern and value of DFI of infertile men in the South West of Nigeria. This is a cross-sectional and descriptive study that recruited two hundred and eighty-seven (287) patients from two fertility centers in Lagos, Nigeria. The Sperm DFI was determined using the Sperm chromatin structure assay (SCSA) test. The descriptive and inferential statistics of the study were carried out using R packages (R version 4.2.0) with the help of R functions using compiled code. The result showed that the mean age sperm concentration, total motility morphology, and DFI were as follows 42.96 ± 7.09 years, 40.18 ± 4.19 × 10⁶ per ml, 49% ± 19%, 56 ± 17%, and 15.78 ± 8.52 respectively. There is a significant negative correlation between sperm concentration and DFI at a P-value of 0.0018 with a regression model of Coefficient of determination is 0.305. The DFI value of infertile men negatively correlates with sperm concentration, thus increase sperm production may improve sperm quality.

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尼日利亚西南部不育男性精子 DNA 碎片指数的模式和价值及其与精子图的相关性

由于精子 DNA 碎片指数（DFI）描述的是精子 DNA 的状况，因此它是评估男性生育能力的适当标准。本研究评估了尼日利亚西南部不育男性的 DFI 模式和价值。这是一项横断面描述性研究，从尼日利亚拉各斯的两家生育中心招募了 287 名患者。精子染色质结构检测法（SCSA）测试确定了精子DFI。研究的描述性和推论性统计使用 R 软件包（R 版本 4.2.0），并在 R 函数的帮助下使用编译代码进行。结果显示，平均年龄精子浓度、总活力形态和 DFI 分别为 42.96 ± 7.09 岁、40.18 ± 4.19 × 106 每毫升、49% ± 19%、56 ± 17% 和 15.78 ± 8.52。精子浓度与 DFI 之间存在明显的负相关，P 值为 0.0018，回归模型的决定系数为 0.305。不育男性的 DFI 值与精子浓度呈负相关，因此增加精子产量可提高精子质量。

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来源期刊

Morphologie Medicine-Anatomy

CiteScore

2.30

自引率

0.00%

发文量

150

审稿时长

25 days

期刊介绍： Morphologie est une revue universitaire avec une ouverture médicale qui sa adresse aux enseignants, aux étudiants, aux chercheurs et aux cliniciens en anatomie et en morphologie. Vous y trouverez les développements les plus actuels de votre spécialité, en France comme a international. Le objectif de Morphologie est d?offrir des lectures privilégiées sous forme de revues générales, d?articles originaux, de mises au point didactiques et de revues de la littérature, qui permettront notamment aux enseignants de optimiser leurs cours et aux spécialistes d?enrichir leurs connaissances.

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