Widespread xanthomas regression by personalized lipid lowering therapy in heterozygous familial hypercholesterolemia

Francesco Sbrana, Beatrice Dal Pino, Federico Bigazzi, Tiziana Sampietro
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Abstract

“The lower, the better” is the recommended approach in the management of high LDL cholesterol. Unfortunately, this does not always achieve as in the case of a 69-year-old woman referred to our Institute for her lipid profile (LDL cholesterol 412 mg/dl), bilateral xanthelasma and cutaneous xanthomas. With a maximized and personalized lipid-lowering therapies (rosuvastatin, ezetimibe, PCSK9i and lipoprotein apheresis), after only six months, the patient showed an impressive regression in her cutaneous xanthomas.

杂合子家族性高胆固醇血症患者通过个性化降脂治疗广泛消退黄瘤
"越低越好 "是治疗高低密度脂蛋白胆固醇的推荐方法。遗憾的是,这并不总能实现,就像一位因血脂异常(低密度脂蛋白胆固醇 412 毫克/分升)、双侧黄疽和皮肤黄瘤转诊到我院的 69 岁女性患者一样。通过最大化和个性化的降脂疗法(洛伐他汀、依折麦布、PCSK9i和脂蛋白分离),仅六个月后,患者的皮肤黄瘤就出现了令人印象深刻的消退。
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