The clinical significance of calcium/magnesium ratio in primary hyperparathyroidism: unveiling a clinical association.

IF 2.4 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Hormones-International Journal of Endocrinology and Metabolism Pub Date : 2024-09-01 Epub Date: 2024-02-09 DOI:10.1007/s42000-024-00530-5

Ekin Yiğit Köroğlu, Abbas Ali Tam, Sevgül Fakı, Belma Tural Balsak, Fatma Ayça Edis Özdemir, Didem Özdemir, Oya Topaloğlu, Reyhan Ersoy, Bekir Çakır

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引用次数: 0

Abstract

Purpose: In previous studies, magnesium (Mg) was found to be lower in cases with more severe primary hyperparathyroidism (PHPT) and higher calcium (Ca) levels. This study evaluated the relationship between serum Mg and serum Ca and phosphorus (P) levels in PHPT and their utility in determining the presence of osteoporosis and nephrolithiasis.

Methods: Patients who were followed up with PHPT between March 2019 and March 2023 were analyzed retrospectively. Biochemical data, renal ultrasonography results, dual-energy x-ray absorptiometry (DEXA) reports, and technetium 99 m sestamibi parathyroid scintigraphy reports were obtained. MgxP, Mg/P, Ca/P, and corrected Ca (cCa)/P values were calculated. The relationships between biochemical parameters and clinical outcomes were evaluated statistically.

Results: A total of 543 patients were included in the study. Patients with nephrolithiasis had higher cCa/Mg or Ca/Mg than those without nephrolithiasis. Additionally, ROC analysis revealed that cCa/Mg greater than 5.24 could identify the presence of nephrolithiasis with a sensitivity of 73.3% and a specificity of 73%. No statistically significant correlation existed between the results of the Mg/P, MgxP, cCa/Mg, Ca/Mg values, and DEXA-bone mineral densitometry(BMD).

Conclusion: Ca/Mg and cCa/Mg ratios in particular seem more valuable in determining the presence of nephrolithiasis than the currently used 24-h urine Ca measurement. Compared to urinary Ca measurements, they are cheaper, more practical, and more accessible.

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原发性甲状旁腺功能亢进症患者钙镁比值的临床意义：揭示临床关联。

目的：在以往的研究中发现，原发性甲状旁腺功能亢进症（PHPT）患者的镁（Mg）含量较低，而钙(Ca)含量较高。本研究评估了PHPT患者血清镁、血清钙和磷水平之间的关系，以及它们在确定是否存在骨质疏松症和肾结石方面的作用：对2019年3月至2023年3月期间随访的PHPT患者进行回顾性分析。方法：对 2019 年 3 月至 2023 年 3 月期间随访的 PHPT 患者进行回顾性分析，获取生化数据、肾脏超声波检查结果、双能 X 射线吸收测定（DEXA）报告和锝 99 m sestamibi 甲状旁腺闪烁扫描报告。计算了 MgxP、Mg/P、Ca/P 和校正 Ca (cCa)/P 值。对生化指标与临床结果之间的关系进行统计评估：研究共纳入了 543 名患者。肾结石患者的 cCa/Mg 或 Ca/Mg 均高于无肾结石患者。此外，ROC 分析表明，cCa/Mg 大于 5.24 可以确定肾炎的存在，灵敏度为 73.3%，特异性为 73%。Mg/P、MgxP、cCa/Mg、Ca/Mg 值与 DEXA-骨矿物质密度测量（BMD）结果之间不存在统计学意义上的相关性：结论：与目前使用的 24 小时尿钙测量相比，钙/镁比值和钙/镁比值在确定是否存在肾炎方面似乎更有价值。与尿钙测量相比，它们更便宜、更实用、更容易获得。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormones-International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hormones-International Journal of Endocrinology and Metabolism is an international journal published quarterly with an international editorial board aiming at providing a forum covering all fields of endocrinology and metabolic disorders such as disruption of glucose homeostasis (diabetes mellitus), impaired homeostasis of plasma lipids (dyslipidemia), the disorder of bone metabolism (osteoporosis), disturbances of endocrine function and reproductive capacity of women and men. Hormones-International Journal of Endocrinology and Metabolism particularly encourages clinical, translational and basic science submissions in the areas of endocrine cancers, nutrition, obesity and metabolic disorders, quality of life of endocrine diseases, epidemiology of endocrine and metabolic disorders.