PD-L2 expression in senescent cancer cells limits tumor clearance after chemotherapy

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-02-08 DOI:10.1038/s43018-023-00713-w

引用次数: 0

Abstract

Senescent cancer cells, which are characteristically present in tumors after genotoxic therapies, upregulate the immune checkpoint ligand programmed cell death 1 ligand 2 (PD-L2). We show that genetic or pharmacological ablation of PD-L2 prevents the accumulation of intratumoral senescent cells, reducing the recruitment of immunosuppressive myeloid cells and facilitating tumor clearance by T cells.

Abstract Image

查看原文本刊更多论文

衰老癌细胞中 PD-L2 的表达限制了化疗后肿瘤的清除。

衰老癌细胞是基因毒性疗法后肿瘤中出现的特征性细胞，它们会上调免疫检查点配体程序性细胞死亡1配体2（PD-L2）。我们的研究表明，通过基因或药物消减 PD-L2 可以防止瘤内衰老细胞的聚集，减少免疫抑制性髓系细胞的招募，促进 T 细胞清除肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.

文献相关原料

公司名称	产品信息	采购帮参考价格