Meta-analysis on Asymptomatic Endometrial Thickening and Its Association with Endometrial Cancer Risk in Women Over 50 Years of Age.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01

Jie Cai, Yanni Huang, Qiaoyun Li

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引用次数: 0

Abstract

Purpose: This study systematically assesses the correlation between asymptomatic endometrial thickening after the age of 50 and the risk of endometrial cancer (EC).

Methods: A comprehensive search was conducted using the Cochrane Library, Web of Science, PubMed, ProQuest, and Chinese biomedical literature databases Wanfang, Weipu, and CNG until August 2022. The included literature was analyzed using RevMan 5.3 software to explore heterogeneity in each study.

Results: Five studies were finally included. The assessment of odds ratio (OR) heterogeneity between women with endometrial thickening and the risk of EC showed P = .18, I2=95%, indicating significant heterogeneity. A random-effects model was applied for meta-analysis, revealing a result of 0.96, 95% CI (0.92, 1.02), P = .18, indicating no statistical significance between the two groups (P > .05). The funnel plot demonstrated asymmetry, suggesting evident publication bias.

Conclusion: There is no consistent correlation between asymptomatic endometrial thickening and the occurrence of EC in individuals over 50 years of age.

本刊更多论文

关于 50 岁以上女性无症状子宫内膜增厚及其与子宫内膜癌风险关系的 Meta 分析。

目的：本研究系统评估了50岁以后无症状子宫内膜增厚与子宫内膜癌（EC）风险之间的相关性：利用Cochrane图书馆、Web of Science、PubMed、ProQuest和中国生物医学文献数据库万方、维普和CNG进行了全面检索，检索期至2022年8月。使用RevMan 5.3软件对纳入的文献进行分析，以探讨每项研究的异质性：结果：最终纳入了五项研究。子宫内膜增厚妇女与EC风险之间的几率比（OR）异质性评估显示P=0.18，I2=95%，表明存在显著异质性。采用随机效应模型进行荟萃分析，结果为0.96，95% CI (0.92，1.02)，P = .18，表明两组间无统计学意义（P > .05）。漏斗图显示不对称，表明存在明显的发表偏倚：结论：在50岁以上的人群中，无症状子宫内膜增厚与EC的发生之间没有一致的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.