Extracellular Vesicles Obtained From Lung Adenocarcinoma Cells Cultured Under Intermittent Hypoxia Induce M2 Macrophage Polarization via miR-20a-5p Delivery.

IF 2.7 4区医学 Q3 ONCOLOGY

Technology in Cancer Research & Treatment Pub Date : 2024-01-01 DOI:10.1177/15330338231219415

Yuanling Liu, Minzhen Lu, Feng Liu, Gang Xu, Congrui Feng, Yuluo Chen, Danyan Cai, Huake Sun, Yanjun Zeng, Jian Xie, Wei Ma, Xinglin Gao

引用次数: 0

Abstract

Conclusion: These findings indicate that EVs obtained from lung adenocarcinoma cells cultured under IH deliver miR-20a-5p to promote M2 macrophage polarization by targeting PTEN.

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间歇性缺氧条件下培养的肺腺癌细胞产生的胞外囊泡通过 miR-20a-5p 递送诱导 M2 巨噬细胞极化

结论这些研究结果表明，从在 IH 条件下培养的肺腺癌细胞中获得的 EVs 可传递 miR-20a-5p，通过靶向 PTEN 促进 M2 巨噬细胞极化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Technology in Cancer Research & Treatment 医学-肿瘤学

CiteScore

4.40

自引率

0.00%

发文量

202

审稿时长

2 months

期刊介绍： Technology in Cancer Research & Treatment (TCRT) is a JCR-ranked, broad-spectrum, open access, peer-reviewed publication whose aim is to provide researchers and clinicians with a platform to share and discuss developments in the prevention, diagnosis, treatment, and monitoring of cancer.