Incidence of prostate cancer in transgender women in the US: a large database analysis.

IF 5.1 2区 医学 Q1 ONCOLOGY
Matthew Loria, David Gilbert, Tomasz Tabernacki, Mart Andrew Maravillas, Megan McNamara, Shubham Gupta, Kirtishri Mishra
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Abstract

The risk of prostate cancer among transgender women undergoing medical and surgical gender-affirming interventions remains unclear, though up to a fivefold decreased risk has been reported in comparison to cisgender men. In this study, we conducted a comparative analysis of the risk of prostate cancer among transgender women (TW) using data from TriNetX, a large database, versus SEER. Our findings indicate that, overall, transgender women exhibited a 2.56-fold lower risk of prostate cancer compared to cisgender men. Specifically, among TW on hormone therapy between ages 50-64, we observed a 2.06-fold decrease in risk. Contrary to the previous perception of prostate cancer being rare in transgender women, our study suggests that it may not be as uncommon as previously believed.

美国变性女性的前列腺癌发病率:大型数据库分析。
接受医学和外科性别确认干预的变性女性罹患前列腺癌的风险仍不清楚,不过有报道称,与同性别的男性相比,变性女性罹患前列腺癌的风险最多可降低五倍。在这项研究中,我们利用大型数据库 TriNetX 和 SEER 的数据对变性女性(TW)罹患前列腺癌的风险进行了比较分析。我们的研究结果表明,总体而言,变性女性患前列腺癌的风险比同性男性低 2.56 倍。具体来说,在 50-64 岁接受激素治疗的 TW 中,我们观察到其风险降低了 2.06 倍。与以往认为变性女性很少罹患前列腺癌的看法相反,我们的研究表明,变性女性罹患前列腺癌的情况可能并不像以往认为的那样少见。
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来源期刊
Prostate Cancer and Prostatic Diseases
Prostate Cancer and Prostatic Diseases 医学-泌尿学与肾脏学
CiteScore
10.00
自引率
6.20%
发文量
142
审稿时长
6-12 weeks
期刊介绍: Prostate Cancer and Prostatic Diseases covers all aspects of prostatic diseases, in particular prostate cancer, the subject of intensive basic and clinical research world-wide. The journal also reports on exciting new developments being made in diagnosis, surgery, radiotherapy, drug discovery and medical management. Prostate Cancer and Prostatic Diseases is of interest to surgeons, oncologists and clinicians treating patients and to those involved in research into diseases of the prostate. The journal covers the three main areas - prostate cancer, male LUTS and prostatitis. Prostate Cancer and Prostatic Diseases publishes original research articles, reviews, topical comment and critical appraisals of scientific meetings and the latest books. The journal also contains a calendar of forthcoming scientific meetings. The Editors and a distinguished Editorial Board ensure that submitted articles receive fast and efficient attention and are refereed to the highest possible scientific standard. A fast track system is available for topical articles of particular significance.
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