Fractal Changes of the Retinal Microvasculature in Syphilitic Uveitis.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2024-11-01 Epub Date: 2024-02-07 DOI:10.1080/09273948.2024.2309280

Marco H Ji, Kaersti L Rickels, Tianyuan Yao, Abdelrahman M Elhusseiny, Michalis Georgiou, Ahmed F Shakarchi, Sami B Uwaydat, Ryan K Dare, Ahmed B Sallam

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引用次数: 0

Abstract

Purpose: To quantify chorioretinal microvascular damage and recovery post-treatment in patients with acute syphilitic posterior placoid chorioretinitis (ASPPC) using fractal dimension (FD).

Methods: Retrospective cohort study of patients with serologically confirmed syphilitic uveitis. We obtained optical coherence tomography angiography (OCTA) scans at baseline and follow-up after intravenous penicillin treatment and computed FD of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) using ImageJ.

Results: We enrolled seven patients with ASPPC (11 eyes), and 17 control subjects (34 eyes). Pre-treatment averages of FD-SCP, FD-DCP, and FD-CC were: 1.672 (±0.115), 1.638 (±0.097), and 1.72 (±0.137); post-treatment: 1.760 (±0.071), 1.764 (±0.043), and 1.898 (±0.047). After treatment FD-CC increased in all 11 eyes with an average of 0.163 (p = 0.003); FD-DCP increased in 10 (91%) eyes with an average of 0.126 (p = 0.003); and FD-SCP increased in seven (64%) eyes with an average of 0.089 (p = 0.059). Compared to the post-treatment FD values in the syphilitic group, controls had similar FD-SCP (p = 0.266), FD-DCP (p = 0.078), and FD-CC (p = 0.449).

Conclusions: CC and DCP are mostly affected in ASPPC with minimal changes in the SCP. All vascular layers FD recovered after completing antibiotic treatment.

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梅毒性葡萄膜炎视网膜微血管的分形变化

目的：使用分形维度（FD）量化急性梅毒性后胎盘状脉络膜视网膜炎（ASPPC）患者的脉络膜微血管损伤和治疗后的恢复情况：方法：对血清学确诊的梅毒性葡萄膜炎患者进行回顾性队列研究。我们在基线和静脉注射青霉素治疗后的随访中获得了光学相干断层血管造影（OCTA）扫描，并使用 ImageJ 计算了浅毛细血管丛（SCP）、深毛细血管丛（DCP）和绒毛膜（CC）的分形维度（FD）：我们招募了 7 名 ASPPC 患者（11 眼）和 17 名对照组受试者（34 眼）。治疗前 FD-SCP、FD-DCP 和 FD-CC 的平均值分别为1.672（±0.115）、1.638（±0.097）和1.72（±0.137）；治疗后：治疗后：1.760（±0.071）、1.764（±0.043）和 1.898（±0.047）。治疗后，所有 11 只眼睛的 FD-CC 均有所增加，平均值为 0.163（p = 0.003）；10 只（91%）眼睛的 FD-DCP 均有所增加，平均值为 0.126（p = 0.003）；7 只（64%）眼睛的 FD-SCP 均有所增加，平均值为 0.089（p = 0.059）。与梅毒组治疗后的 FD 值相比，对照组的 FD-SCP（p = 0.266）、FD-DCP（p = 0.078）和 FD-CC （p = 0.449）相似：结论：在 ASPPC 中，CC 和 DCP 受影响最大，SCP 变化最小。完成抗生素治疗后，所有血管层 FD 均可恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.