Metagenomic Analysis Reveals Difference of Gut Microbiota in ADHD.

IF 2.7 3区医学 Q2 PSYCHIATRY

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2024-02-07 DOI:10.1177/10870547231225491

Ning Wang, Haibin Wang, Yu Bai, Yilu Zhao, Xiangyu Zheng, Xuping Gao, Zifeng Zhang, Li Yang

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引用次数: 0

Abstract

Objective: Although ADHD is highly heritable, some environmental factors contribute to its development. Given the growing evidence that gut microbiota was involved in psychiatric disorders, we aimed to identify the characteristic composition of the gut microbiota in ADHD.

Methods: We recruited 47 medication-naive children and adolescents with ADHD, and 60 healthy controls (HCs). We used shotgun metagenomics to measure the structure of the gut microbiota and analyzed the difference in bacterial taxa between ADHD and HCs.

Results: Significant differences were found between the ADHD and HC groups in both alpha diversity indices (Simpson index, p = .025 and Shannon index, p = .049) and beta diversity indices (Euclidean distance, Bray-Curtis distance, and JSD distance, p < 2.2e-16). Nine representative species best explain the difference.

Conclusion: Patients with ADHD showed significant differences in the composition of the gut microbiota compared with HCs. These results may help identify potential biomarkers of ADHD.

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元基因组分析揭示多动症患者肠道微生物群的差异

目的：虽然多动症具有高度遗传性，但一些环境因素也会导致多动症的发生。鉴于越来越多的证据表明肠道微生物群与精神疾病有关，我们旨在确定多动症患者肠道微生物群的特征性组成：我们招募了 47 名未接受药物治疗的多动症儿童和青少年，以及 60 名健康对照组（HCs）。我们使用枪式元基因组学测量了肠道微生物群的结构，并分析了ADHD和HC之间细菌类群的差异：结果：ADHD组和HC组在α多样性指数（辛普森指数，p = .025；香农指数，p = .049）和β多样性指数（欧氏距离、布雷-柯蒂斯距离和JSD距离，p 结论：ADHD组和HC组在α多样性指数和β多样性指数上存在显著差异：与普通人相比，多动症患者的肠道微生物群组成存在明显差异。这些结果可能有助于确定多动症的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Attention Disorders PSYCHIATRY-

CiteScore

7.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Attention Disorders (JAD) focuses on basic and applied science concerning attention and related functions in children, adolescents, and adults. JAD publishes articles on diagnosis, comorbidity, neuropsychological functioning, psychopharmacology, and psychosocial issues. The journal also addresses practice, policy, and theory, as well as review articles, commentaries, in-depth analyses, empirical research articles, and case presentations or program evaluations.