Effects of Traditional Chinese Medicine "Fuzheng Qingdu Decoction" on Autonomic Function and Cancer-Related Symptoms in Patients with Advanced Gastric Cancer undergoing Chemotherapy: A Controlled Trial.

IF 2.9 3区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
Chengjia Yuan, Shuang Wu, Yang Wu, Cuiling Tian, Zaichuan Wang, Xiaochun Zhang
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引用次数: 0

Abstract

Objective: To evaluate the effects of Fuzheng Qingdu Decoction (FZQDD) on the autonomic function and cancer-related symptoms of patients with advanced gastric cancer undergoing chemotherapy to verify its clinical efficacy.

Methods: Sixty-two patients with stage III or IV gastric cancer were included in this study. The patients were divided into 2 groups: the chemotherapy (33 patients) and chemotherapy with FZQDD (29 patients) groups. The primary outcome was the autonomic function of the patients before and after the interventions. The parameters that were used to assess autonomic function were deceleration capacity (DC) and acceleration capacity (AC) of heart rate and heart rate variability (HRV), which comprised standard deviation of the normal-normal interval (SDNN), root mean square of successive interval differences (RMSSD), low-frequency power (LF), high-frequency power (HF), total power (TP), and LF-HF ratio. The secondary outcomes were cancer-related symptoms and the quality of life.

Results: DC and HRV parameters (ie, SDNN, RMSSD, LF, HF, and TP) were significantly decreased in the chemotherapy group; however, AC significantly increased after the interventions. No significant differences were observed in the DC, AC, and HRV parameters before and after the interventions in the chemotherapy with FZQDD group. Nevertheless, the changes in DC, AC, and HRV parameters (SDNN, RMSSD, HF, and TP) before and after the interventions were statistically significant between both the groups. FZQDD significantly improved the cancer-related symptoms and the quality of life of the patients.

Conclusions: Oxaliplatin combined with S-1 (tegafur, gimeracil, and oteracil potassium) can impair autonomic modulation in patients with advanced gastric cancer. FZQDD can alleviate autonomic dysfunction by increasing the parasympathetic activity and decreasing the sympathetic tone, helping patients restore the dynamic sympathovagal balance, and significantly improving the cancer-related symptoms and the quality of life of patients.

中药 "扶正清浊汤 "对晚期胃癌化疗患者自主神经功能和癌症相关症状的影响:对照试验。
目的:评估扶正清毒汤对晚期胃癌化疗患者自主神经功能和癌症相关症状的影响:评估扶正清毒汤(FZQDD)对晚期胃癌化疗患者自主神经功能和癌症相关症状的影响,以验证其临床疗效:本研究共纳入62例III期或IV期胃癌患者。将患者分为两组:化疗组(33 例)和化疗联合 FZQDD 组(29 例)。主要结果是干预前后患者的自律神经功能。用于评估自律神经功能的参数是心率减速能力(DC)和加速能力(AC)以及心率变异性(HRV),其中包括正常-正常间期标准差(SDNN)、连续间期差的均方根(RMSSD)、低频功率(LF)、高频功率(HF)、总功率(TP)和 LF-HF 比值。次要结果为癌症相关症状和生活质量:结果:化疗组的直流电和心率变异参数(即 SDNN、RMSSD、LF、HF 和 TP)明显降低;然而,AC 在干预后明显增加。化疗联合 FZQDD 组的 DC、AC 和心率变异参数在干预前后无明显差异。然而,两组患者在干预前后的 DC、AC 和心率变异参数(SDNN、RMSSD、HF 和 TP)的变化均具有统计学意义。FZQDD明显改善了癌症相关症状,提高了患者的生活质量:结论:奥沙利铂联合 S-1(替加氟、吉莫拉嘧啶和奥特拉嘧啶钾)可损害晚期胃癌患者的自主神经调节功能。FZQDD可通过增加副交感神经活性和降低交感神经张力来缓解自律神经功能紊乱,帮助患者恢复动态交感-迷走平衡,显著改善患者的癌症相关症状和生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Integrative Cancer Therapies
Integrative Cancer Therapies 医学-全科医学与补充医学
CiteScore
4.80
自引率
3.40%
发文量
78
审稿时长
>12 weeks
期刊介绍: ICT is the first journal to spearhead and focus on a new and growing movement in cancer treatment. The journal emphasizes scientific understanding of alternative medicine and traditional medicine therapies, and their responsible integration with conventional health care. Integrative care includes therapeutic interventions in diet, lifestyle, exercise, stress care, and nutritional supplements, as well as experimental vaccines, chrono-chemotherapy, and other advanced treatments. Contributors are leading oncologists, researchers, nurses, and health-care professionals.
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