Current understanding of Bordetella-induced cough

IF 1.9 4区 医学 Q4 IMMUNOLOGY
Yasuhiko Horiguchi
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Abstract

Typical pathogenic bacteria of the genus Bordetella cause respiratory diseases, many of which are characterized by severe coughing in host animals. In human infections with these bacteria, such as whooping cough, coughing imposes a heavy burden on patients. The pathophysiology of this severe coughing had long been uncharacterized because convenient animal models that reproduce Bordetella-induced cough have not been available. However, rat and mouse models were recently shown as useful for understanding, at least partially, the causative factors and the mechanism of Bordetella-induced cough. Many types of coughs are induced under various physiological conditions, and the neurophysiological pathways of coughing are considered to vary among animal species, including humans. However, the neurophysiological mechanisms of the coughs in different animal species have not been entirely understood, and, accordingly, the current understanding of Bordetella-induced cough is still incomplete. Nevertheless, recent research findings may open the way for the development of prophylaxis and therapeutic measures against Bordetella-induced cough.

Abstract Image

目前对博德特氏菌引起的咳嗽的认识。
博德特氏菌属的典型致病菌会引起呼吸道疾病,其中许多疾病的特征是宿主动物剧烈咳嗽。在人类感染这些细菌(如百日咳)时,咳嗽会给患者带来沉重的负担。长期以来,这种剧烈咳嗽的病理生理学一直没有定性,因为没有方便的动物模型来再现博德特氏菌引起的咳嗽。然而,最近的研究表明,大鼠和小鼠模型有助于了解至少部分博德特氏菌诱发咳嗽的致病因素和机制。在不同的生理条件下会诱发多种类型的咳嗽,不同动物物种(包括人类)咳嗽的神经生理途径也不尽相同。然而,不同动物物种咳嗽的神经生理机制尚未完全清楚,因此,目前对博德特氏菌诱发咳嗽的认识仍不全面。尽管如此,最近的研究成果可能为开发针对博德特氏菌引起的咳嗽的预防和治疗措施开辟了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Microbiology and Immunology
Microbiology and Immunology 医学-免疫学
CiteScore
5.20
自引率
3.80%
发文量
78
审稿时长
1 months
期刊介绍: Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.
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