Precursor lesions in familial and hereditary pancreatic cancer.

IF 1.8 4区医学 Q3 GENETICS & HEREDITY

Familial Cancer Pub Date : 2024-08-01 Epub Date: 2024-02-06 DOI:10.1007/s10689-024-00359-2

Michael J Pflüger, Lodewijk A A Brosens, Ralph H Hruban

引用次数: 0

Abstract

Infiltrating ductal adenocarcinoma of the pancreas, referred to here as "pancreatic cancer," is one of the deadliest of all of the solid malignancies. The five-year survival rate in the United States for individuals diagnosed today with pancreatic cancer is a dismal 12%. Many invasive cancers, including pancreatic cancer, however, arise from histologically and genetically well-characterized precursor lesions, and these precancers are curable. Precursor lesions therefore are an attractive target for early detection and treatment. This is particularly true for individuals with an increased risk of developing invasive cancer, such as individuals with a strong family history of pancreatic cancer, and individuals with a germline variant known to increase the risk of developing pancreatic cancer. There is therefore a need to understand the precursor lesions that can give rise to invasive pancreatic cancer in these individuals.

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家族性和遗传性胰腺癌的前驱病变。

胰腺浸润性导管腺癌在这里被称为 "胰腺癌"，是所有实体瘤中最致命的恶性肿瘤之一。在美国，目前确诊胰腺癌患者的五年生存率仅为 12%。然而，包括胰腺癌在内的许多浸润性癌症都是由组织学和遗传学特征良好的前驱病变引起的，而且这些前驱病变是可以治愈的。因此，前驱病变是早期检测和治疗的一个有吸引力的目标。对于罹患浸润性癌症风险较高的人来说尤其如此，例如有胰腺癌家族史的人，以及有已知会增加胰腺癌罹患风险的种系变异的人。因此，有必要了解这些人患上浸润性胰腺癌的前驱病变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Familial Cancer 医学-遗传学

CiteScore

4.10

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： In recent years clinical cancer genetics has become increasingly important. Several events, in particular the developments in DNA-based technology, have contributed to this evolution. Clinical cancer genetics has now matured to a medical discipline which is truly multidisciplinary in which clinical and molecular geneticists work together with clinical and medical oncologists as well as with psycho-social workers. Due to the multidisciplinary nature of clinical cancer genetics most papers are currently being published in a wide variety of journals on epidemiology, oncology and genetics. Familial Cancer provides a forum bringing these topics together focusing on the interests and needs of the clinician. The journal mainly concentrates on clinical cancer genetics. Most major areas in the field shall be included, such as epidemiology of familial cancer, molecular analysis and diagnosis, clinical expression, treatment and prevention, counselling and the health economics of familial cancer.