Unraveling the Therapeutic Potential of Muscle Strengthening Exercises for Reversing Diabetes Mellitus.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Haajeera Samsudeen, Shree Pavithra D, Krishnaveni Kandasamy
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引用次数: 0

Abstract

Background: Millions of people worldwide are affected by the serious consequences of diabetes mellitus, which is a major global health concern. We analyze the possibility of muscle- strengthening activities as an appropriate therapeutic strategy for controlling the progression of diabetes mellitus in this comprehensive review. In this review, we explore the molecular processes underlying the glucose uptake in skeletal muscle, revealing how exercise can improve insulin sensitivity and glucose homeostasis.

Methodology: Articles published between 2010 and 2023 were analyzed in detail by using bibliographic databases like PubMed, Medline, and Scopus. The most commonly searched terms were "muscle strengthening exercises," "diabetes mellitus," "insulin resistance," "glucose uptake," "skeletal muscle," and even "exercise therapy." The inclusion criteria were randomized controlled trials, observational studies, and systematic reviews. This allowed for the selection of sources that were related to the topic at hand and were reliable.

Results: This review highlights the benefits of exercise for diabetes mellitus, elucidating the positive effects of acute and regular exercise on glucose uptake in skeletal muscle. It also analyzes the impact of various exercise modalities, including aerobic and resistance exercises, on glucose metabolism in individuals with and without type 2 diabetes. Furthermore, this review examines the effectiveness of combining aerobic and resistance training for optimal diabetes management.

Conclusion: Our analysis reveals promising evidence supporting the role of resistance training in diabetes mellitus reversal. Regular resistance exercise has been shown to improve glycemic control, insulin sensitivity, and muscle function in individuals with type 2 diabetes. Combining aerobic and resistance exercises appears to be more effective than single-mode training in managing blood glucose levels and enhancing overall metabolic health. However, Resistance training implementation challenges, as well as potential exercise contraindications in diabetic patients, warrant further studies.

揭示肌肉强化训练对逆转糖尿病的治疗潜力。
背景:全世界有数百万人受到糖尿病严重后果的影响,糖尿病是全球主要的健康问题。在这篇综述中,我们分析了肌肉强化活动作为控制糖尿病进展的适当治疗策略的可能性。在这篇综述中,我们探讨了骨骼肌葡萄糖摄取的分子过程,揭示了运动如何改善胰岛素敏感性和葡萄糖稳态:使用 PubMed、Medline 和 Scopus 等文献数据库对 2010 年至 2023 年间发表的文章进行了详细分析。最常搜索的术语是 "肌肉强化训练"、"糖尿病"、"胰岛素抵抗"、"葡萄糖摄取"、"骨骼肌 "甚至 "运动疗法"。纳入标准包括随机对照试验、观察研究和系统综述。这样就可以选择与当前主题相关且可靠的资料来源:本综述强调了运动对糖尿病的益处,阐明了急性和定期运动对骨骼肌葡萄糖摄取的积极影响。综述还分析了各种运动方式(包括有氧运动和阻力运动)对 2 型糖尿病患者和非 2 型糖尿病患者葡萄糖代谢的影响。此外,这篇综述还探讨了有氧运动和阻力训练相结合对优化糖尿病管理的效果:我们的分析揭示了支持阻力训练在糖尿病逆转中发挥作用的有希望的证据。事实证明,定期进行抗阻力训练可改善 2 型糖尿病患者的血糖控制、胰岛素敏感性和肌肉功能。在控制血糖水平和提高整体代谢健康方面,结合有氧运动和阻力训练似乎比单一模式的训练更有效。然而,阻力训练实施过程中的挑战以及糖尿病患者潜在的运动禁忌症值得进一步研究。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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