[IgD expression in various immunoarchitectural patterns of nodular lymphocyte predominant Hodgkin lymphoma in children].

Q4 Medicine

Arkhiv patologii Pub Date : 2024-01-01 DOI:10.17116/patol20248601121

M A Senchenko, D M Konovalov

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引用次数: 0

Abstract

Background: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) consist of lymphocyte predominant cell or LP-cell. Despite their origin from active germinal centers, in some cases LP-cells express IgD, which is characteristic of naive B-lymphocytes of the mantle zone. Due to the rarity of NLPHL, assessing the frequency of IgD-positive cases is difficult. This marker can serve not only for differential diagnosis with other diseases, but also indicate the possible heterogeneity of NLPHL, which is currently represented by six immunoarchitectural patterns.

Objective: To determine the frequency of IgD-positive cases of NLPHL in children with subsequent assessment of the association with types of immunoarchitectural patterns.

Material and methods: The study included 52 cases of NLPHL, which were divided to typical and atypical patterns. Differences between two groups were compared using Fisher's exact tests.

Results: IgD expression was found in LP-cells in 26 of 52 cases (50%) and was positively correlated with atypical types (typical - 5/23, 21.7% vs atypical - 21/29, 72.4%, p=0.0003), among which pattern C was most common.

Conclusion: Due to the high incidence of IgD-positive cases in NLPHL, this marker may be useful in differential diagnosis with histologic mimics. At the same time, positive IgD status was associated with atypical patterns, which may likely determine the different biology of neoplastic cells within the same form.

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[儿童结节性淋巴细胞占优势的霍奇金淋巴瘤各种免疫结构模式中的 IgD 表达]。

背景：结节性淋巴细胞优势霍奇金淋巴瘤（NLPHL）由淋巴细胞优势细胞或 LP 细胞组成。尽管LP细胞来源于活跃的生殖中心，但在某些情况下，LP细胞会表达IgD，这是套层区幼稚B淋巴细胞的特征。由于 NLPHL 的罕见性，很难评估 IgD 阳性病例的频率。这一标志物不仅可用于与其他疾病的鉴别诊断，还可显示NLPHL可能存在的异质性，目前NLPHL有六种免疫结构模式：目的：确定儿童 IgD 阳性 NLPHL 病例的频率，随后评估与免疫结构模式类型的关联：研究包括52例NLPHL病例，分为典型和非典型模式。采用费雪精确检验比较两组之间的差异：52例病例中有26例（50%）在LP细胞中发现了IgD表达，且与非典型型呈正相关（典型型--5/23，21.7% vs 非典型型--21/29，72.4%，P=0.0003），其中C型最为常见：结论：由于IgD阳性病例在NLPHL中的发病率较高，该标记物可能有助于与组织学拟态进行鉴别诊断。同时，IgD阳性与非典型模式有关，这可能决定了同一种类型的肿瘤细胞具有不同的生物学特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arkhiv patologii Medicine-Pathology and Forensic Medicine

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The journal deals with original investigations on pressing problems of general pathology and pathologic anatomy, newest research methods, major issues of the theory and practice as well as problems of experimental, comparative and geographic pathology. To inform readers latest achievements of Russian and foreign medicine the journal regularly publishes editorial and survey articles, reviews of the most interesting Russian and foreign books on pathologic anatomy, new data on modern methods of investigation (histochemistry, electron microscopy, autoradiography, etc.), about problems of teaching, articles on the history of pathological anatomy development both in Russia and abroad.