Sex-related differences in Cushing's disease: a systematic review and meta-analysis.

Annals of Saudi medicine Pub Date : 2024-01-01 Epub Date: 2024-02-01 DOI:10.5144/0256-4947.2024.55

Basel F Alqeeq, Mohammed Ayyad, Waseem J Almadhoun, Mohammad Aboabdo, Mosheer S Aldahdouh, Mohammed Al-Tawil, Ahmed M Al-Ghazali

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Abstract

Background and objectives: Cushing's disease is a rare endocrine disorder. This review aimed to examine sex-specific differences in Cushing's disease.

Design and settings: A meta-analysis was performed on published articles discussing the gender impact of Cushing's disease.

Methods: A systematic search was conducted to identify studies from Medline, Embase, CENTRAL and Scopus. Nine studies enrolling 1047 patients diagnosed with Cushing's disease were included in this meta-analysis.

Results: Male patients presented at a younger age (MD [mean difference]=-5.43; 95% CI [-5.78, -5.08]; P<.00001) than females. Male patients had a significantly higher prevalence of osteoporosis (RR [risk ratio]=1.75; 95% CI [1.36, 225]; P<.0001) and hypokalemia (RR=1.66; 95% CI [1.27, 2.16]; P=.0002). In addition, males had significantly higher rates of negative magnetic resonance imaging (RR=1.53; 95% CI [1.18, 2.0]; P=.002). No sex difference was observed in the prevalence of diabetes (RR=0.92; 95% CI [0.70, 1.22]); P=.57) and dyslipidemia (RR=1.33; 95% CI [0.88, 2.0]; P=.17).

Conclusion: Cushing's disease has a worse clinical presentation in males and more diagnostic difficulties compared to females.

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库欣病的性别差异：系统回顾和荟萃分析。

背景和目的：库欣病是一种罕见的内分泌疾病。本综述旨在研究库欣病的性别差异：对已发表的讨论库欣病性别影响的文章进行荟萃分析：方法：对 Medline、Embase、CENTRAL 和 Scopus 中的研究进行了系统检索。9项研究共纳入了1047名库欣病患者：男性患者发病年龄更小（MD[平均差异]=-5.43；95% CI [-5.78，-5.08]；PPP=.0002）。此外，男性磁共振成像阴性率明显更高（RR=1.53；95% CI [1.18，2.0]；P=.002）。糖尿病（RR=0.92；95% CI [0.70，1.22]）和血脂异常（RR=1.33；95% CI [0.88，2.0]；P=.17）的患病率没有性别差异：结论：与女性相比，男性库欣病的临床表现更差，诊断也更困难。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annals of Saudi medicine

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