Correlation of Female Genital Tuberculosis and Infertility: A Comprehensive Systematic Review, Meta-analysis, and Female Genital Tuberculosis Infertility Pathway Analysis.

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Journal of Mid-life Health Pub Date : 2023-07-01 Epub Date: 2023-12-30 DOI:10.4103/jmh.jmh_151_23

Anushri Vijay, Neha Tiwari, Amita Sharma, Geeta Pandey

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引用次数: 0

Abstract

Female genital tuberculosis (FGTB) is a significant health concern that can lead to infertility in women. FGTB is a common form of tuberculosis that affects the female reproductive organs. In India, around 27.5 million individuals are facing infertility issues due to female factors, and FGTB might be one of the leading causes. A systematic review and proportion meta-analysis of six studies was conducted using MedCalc 20.116 to examine the association between FGTB and infertility. The studies were identified through an electronic search of PubMed, MEDLINE, Elsevier, and the Cochrane Library from 2010 to 2023. The results showed that FGTB is significantly associated with infertility, with a prevalence of approximately 34.86%. These findings underscore the need for effective interventions to improve reproductive health in women with FGTB. Based on pathway analysis, we conclude that more clinical trials should be conducted to explore the potential utilization of interferon gamma and nuclear receptors as therapeutic drug targets and biomarkers for the prevention of FGTB. The findings of this review will contribute to raising awareness, facilitating accurate diagnosis, and improving the management of FGTB-related infertility.

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女性生殖器结核与不孕的相关性：全面系统综述、元分析和女性生殖器结核不孕途径分析》。

女性生殖器结核（FGTB）是一个重要的健康问题，可导致女性不孕。女性生殖器结核是一种影响女性生殖器官的常见结核病。在印度，约有 2750 万人因女性因素而面临不孕问题，而 FGTB 可能是主要原因之一。我们使用 MedCalc 20.116 对六项研究进行了系统回顾和比例荟萃分析，以研究 FGTB 与不孕症之间的关联。这些研究是通过对 2010 年至 2023 年期间的 PubMed、MEDLINE、Elsevier 和 Cochrane 图书馆进行电子检索而确定的。结果显示，FGTB 与不孕症密切相关，发病率约为 34.86%。这些发现强调了采取有效干预措施改善 FGTB 妇女生殖健康的必要性。根据路径分析，我们得出结论，应开展更多临床试验，探索将γ干扰素和核受体作为治疗药物靶点和生物标记物预防 FGTB 的可能性。本综述的研究结果将有助于提高人们对 FGTB 相关不孕症的认识、促进准确诊断和改善管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Mid-life Health Social Sciences-Health (social science)

CiteScore

1.70

自引率

9.10%

发文量

审稿时长

43 weeks

期刊介绍： Journal of mid-life health is the official journal of the Indian Menopause society published Quarterly in January, April, July and October. It is peer reviewed, scientific journal of mid-life health and its problems. It includes all aspects of mid-life health, preventive as well as curative. The journal publishes on subjects such as gynecology, neurology, geriatrics, psychiatry, endocrinology, urology, andrology, psychology, healthy ageing, cardiovascular health, bone health, quality of life etc. as relevant of men and women in their midlife. The Journal provides a visible platform to the researchers as well as clinicians to publish their experiences in this area thereby helping in the promotion of mid-life health leading to healthy ageing, growing need due to increasing life expectancy. The Editorial team has maintained high standards and published original research papers, case reports and review articles from the best of the best contributors both national & international, consistently so that now, it has become a great tool in the hands of menopause practitioners.