Matthias P. Mayer , Laura Blair , Gregory L. Blatch , Thiago J. Borges , Ahmed Chadli , Gabriela Chiosis , Aurélie de Thonel , Albena Dinkova-Kostova , Heath Ecroyd , Adrienne L. Edkins , Takanori Eguchi , Monika Fleshner , Kevin P. Foley , Sotirios Fragkostefanakis , Jason Gestwicki , Pierre Goloubinoff , Jennifer A. Heritz , Christine M. Heske , Jonathan D. Hibshman , Jenny Joutsen , Tawanda Zininga
{"title":"Stress biology: Complexity and multifariousness in health and disease","authors":"Matthias P. Mayer , Laura Blair , Gregory L. Blatch , Thiago J. Borges , Ahmed Chadli , Gabriela Chiosis , Aurélie de Thonel , Albena Dinkova-Kostova , Heath Ecroyd , Adrienne L. Edkins , Takanori Eguchi , Monika Fleshner , Kevin P. Foley , Sotirios Fragkostefanakis , Jason Gestwicki , Pierre Goloubinoff , Jennifer A. Heritz , Christine M. Heske , Jonathan D. Hibshman , Jenny Joutsen , Tawanda Zininga","doi":"10.1016/j.cstres.2024.01.006","DOIUrl":null,"url":null,"abstract":"<div><p>Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.</p></div>","PeriodicalId":9684,"journal":{"name":"Cell Stress & Chaperones","volume":"29 1","pages":"Pages 143-157"},"PeriodicalIF":3.3000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1355814524000464/pdfft?md5=ae52b2fabe5d4714b69d76b11a44f370&pid=1-s2.0-S1355814524000464-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Stress & Chaperones","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1355814524000464","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.
期刊介绍:
Cell Stress and Chaperones is an integrative journal that bridges the gap between laboratory model systems and natural populations. The journal captures the eclectic spirit of the cellular stress response field in a single, concentrated source of current information. Major emphasis is placed on the effects of climate change on individual species in the natural environment and their capacity to adapt. This emphasis expands our focus on stress biology and medicine by linking climate change effects to research on cellular stress responses of animals, micro-organisms and plants.