Novel insights into the post-translational modifications of Ydj1/DNAJA1 co-chaperones

IF 3.3 3区生物学 Q3 CELL BIOLOGY

Cell Stress & Chaperones Pub Date : 2024-02-01 DOI:10.1016/j.cstres.2023.11.001

Megan M. Mitchem , Courtney Shrader , Elizabeth Abedi, Andrew W. Truman

引用次数: 0

Abstract

The activity of the Hsp70 molecular chaperone is regulated by a suite of helper co-chaperones that include J-proteins. Studies on J-proteins have historically focused on their expression, localization, and activation of Hsp70. There is growing evidence that the post-translational modifications (PTMs) of chaperones (the chaperone code) fine-tune chaperone function. This mini-review summarizes the current understanding of the role and regulation of PTMs on the major J-proteins Ydj1 and DNAJA1. Understanding these PTMs may provide novel therapeutic avenues for targeting chaperone activity in cancer and neurodegenerative diseases.

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关于 Ydj1/DNAJA1 协同伴侣翻译后修饰的新见解

Hsp70 分子伴侣的活性受包括 J 蛋白在内的一系列辅助辅助伴侣的调控。对 J 蛋白的研究历来侧重于它们的表达、定位和 Hsp70 的激活。越来越多的证据表明，伴侣蛋白的翻译后修饰（PTMs）（伴侣蛋白代码）可微调伴侣蛋白的功能。这篇微型综述总结了目前对主要 J 蛋白 Ydj1 和 DNAJA1 上 PTM 的作用和调控的理解。了解这些 PTM 可为针对癌症和神经退行性疾病的伴侣活性提供新的治疗途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress & Chaperones 生物-细胞生物学

CiteScore

7.60

自引率

2.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Stress and Chaperones is an integrative journal that bridges the gap between laboratory model systems and natural populations. The journal captures the eclectic spirit of the cellular stress response field in a single, concentrated source of current information. Major emphasis is placed on the effects of climate change on individual species in the natural environment and their capacity to adapt. This emphasis expands our focus on stress biology and medicine by linking climate change effects to research on cellular stress responses of animals, micro-organisms and plants.