Prescriptions of psychotropic and somatic medications among patients with severe mental disorders and healthy controls in a naturalistic study.

IF 1.5 4区 医学 Q3 PSYCHIATRY
Nordic Journal of Psychiatry Pub Date : 2024-04-01 Epub Date: 2024-02-02 DOI:10.1080/08039488.2024.2305806
Dur E Shahnaz Shafi, Kjetil Nordbø Jørgensen, Thomas Bjella, Ragnar Nesvåg, Ingrid Dieset, Ingrid Melle, Ole A Andreassen, Erik G Jönsson
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引用次数: 0

Abstract

Purpose: Psychotropic and somatic medications are both used in treating severe mental disorders (SMDs). Realistic estimates of the prevalence of use across medication categories are needed. We obtained this in a clinical cohort of patients with SMD and healthy controls (HCs).

Materials and methods: Prescriptions filled at Norwegian pharmacies the year before and after admittance to the Thematically Organized Psychosis (TOP) study were examined in 1406 patients with SMD (mean age 32.5 years, 48.2% women) and 920 HC (34.1 years, 46.2% women). Using data from the Norwegian Prescription Database (NorPD), the number of users in different anatomical therapeutic chemical (ATC) categories was compared using logistic regression. Population estimates were used as reference data.

Results: Use of antipsychotics (N05A), antiepileptics (N03A), antidepressants (N06A), anxiolytics (N05B), hypnotics and sedatives (N05C), anticholinergics (N04A), psychostimulants, attention deficit hyperactivity disorder and nootropic agents (N06B) and drugs for addiction disorders (N07B) was significantly more prevalent in patients with SMD than HC. Use of diabetes treatment (A10), antithrombotic drugs (B01), beta blockers (C07), lipid modifiers (C10), and thyroid and endocrine therapeutics (H03) was also more prevalent in patients with SMD, but with two exceptions somatic medication use was comparable to the general population. Among HC, there was low prevalence of use for most medication categories.

Conclusion: Patients were using psychiatric medications, but also several types of somatic medications, more often than HC. Still, somatic medication use was mostly not higher than in the general population. The results indicate that HC had low use of most medication types.

在一项自然研究中,严重精神障碍患者和健康对照组的精神药物和躯体药物处方。
目的:精神药物和躯体药物都被用于治疗严重精神障碍(SMDs)。我们需要对各类药物的使用流行率做出真实的估计。我们在一个由严重精神障碍患者和健康对照组(HCs)组成的临床队列中获得了这一数据:我们对1406名SMD患者(平均年龄32.5岁,48.2%为女性)和920名健康对照组(34.1岁,46.2%为女性)在加入主题性精神病(TOP)研究前后一年在挪威药房开具的处方进行了调查。利用挪威处方数据库(NorPD)的数据,采用逻辑回归法比较了不同解剖学治疗化学(ATC)类别的使用者人数。使用人口估计数作为参考数据:结果:SMD 患者使用抗精神病药(N05A)、抗癫痫药(N03A)、抗抑郁药(N06A)、抗焦虑药(N05B)、催眠药和镇静剂(N05C)、抗胆碱能药(N04A)、精神兴奋剂、注意缺陷多动障碍和促智药(N06B)以及成瘾症药物(N07B)的比例明显高于 HC 患者。糖尿病治疗药物(A10)、抗血栓药物(B01)、β受体阻滞剂(C07)、血脂调节剂(C10)以及甲状腺和内分泌治疗药物(H03)在 SMD 患者中的使用率也较高,但除两种情况外,躯体药物的使用率与普通人群相当。在高危人群中,大多数药物类别的使用率较低:结论:患者使用精神科药物和几种躯体药物的频率都高于高危人群。不过,躯体药物的使用率大多不高于普通人群。结果表明,高危人群对大多数药物类型的使用率较低。
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来源期刊
Nordic Journal of Psychiatry
Nordic Journal of Psychiatry 医学-精神病学
CiteScore
3.60
自引率
5.60%
发文量
86
审稿时长
12 months
期刊介绍: Nordic Journal of Psychiatry publishes international research on all areas of psychiatry. Nordic Journal of Psychiatry is the official journal for the eight psychiatry associations in the Nordic and Baltic countries. The journal aims to provide a leading international forum for high quality research on all themes of psychiatry including: Child psychiatry Adult psychiatry Psychotherapy Pharmacotherapy Social psychiatry Psychosomatic medicine Nordic Journal of Psychiatry accepts original research articles, review articles, brief reports, editorials and letters to the editor.
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